Predictive modelling of complex agronomic and biological systems

Authors

Errata

This article is corrected by:

  1. Errata: Erratum Volume 36, Issue 10, 1910, Article first published online: 3 September 2013

  • [Copyright line has been changed since first online publication on 04 July 2013.]

Correspondence: J. J. B. Keurentjes. e-mail: joost.keurentjes@wur.nl

Abstract

Biological systems are tremendously complex in their functioning and regulation. Studying the multifaceted behaviour and describing the performance of such complexity has challenged the scientific community for years. The reduction of real-world intricacy into simple descriptive models has therefore convinced many researchers of the usefulness of introducing mathematics into biological sciences. Predictive modelling takes such an approach another step further in that it takes advantage of existing knowledge to project the performance of a system in alternating scenarios. The ever growing amounts of available data generated by assessing biological systems at increasingly higher detail provide unique opportunities for future modelling and experiment design. Here we aim to provide an overview of the progress made in modelling over time and the currently prevalent approaches for iterative modelling cycles in modern biology. We will further argue for the importance of versatility in modelling approaches, including parameter estimation, model reduction and network reconstruction. Finally, we will discuss the difficulties in overcoming the mathematical interpretation of in vivo complexity and address some of the future challenges lying ahead.

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