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  • Belhocine, T.Z., Scott, A.M., Even-Sapir, E., Urbain, J.L., and Essner, R. (2006). Role of nuclear medicine in the management of cutaneous malignant melanoma. J. Nucl. Med. 47, 957967.
  • Cai, Q., Lin, T., Kamarajugadda, S., and Lu, J. (2012). Regulation of glycolysis and the Warburg effect by estrogen-related receptors. Oncogene [E-pub ahead of print] doi: 10.1038/onc.2012.221.
  • Carvalho, M.A., Zecchin, K.G., Seguin, F. et al. (2008). Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. Int. J. Cancer 123, 25572565.
  • Cheng, T., Sudderth, J., Yang, C., Mullen, A.R., Jin, E.S., Mates, J.M., and DeBerardinis, R.J. (2011). Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. Proc. Natl. Acad. Sci. USA 108, 86748679.
  • Dang, L., White, D.W., Gross, S. et al. (2009). Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739744.
  • DeBerardinis, R.J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., and Thompson, C.B. (2007). Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. USA 104, 1934519350.
  • Delage, B., Fennell, D.A., Nicholson, L., McNeish, I., Lemoine, N.R., Crook, T., and Szlosarek, P.W. (2010). Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. Int. J. Cancer 126, 27622772.
  • Dillon, B.J., Prieto, V.G., Curley, S.A., Ensor, C.M., Holtsberg, F.W., Bomalaski, J.S., and Clark, M.A. (2004). Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation. Cancer 100, 826833.
  • Filipp, F.V., Scott, D.A., Ronai, Z.A., Osterman, A.L., and Smith, J.W. (2012). Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Res. 25, 375383.
  • Fosslien, E. (2008). Cancer morphogenesis: role of mitochondrial failure. Ann. Clin. Lab. Sci. 38, 307329.
  • Frezza, C., Zheng, L., Folger, O. et al. (2011). Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature 477, 225228.
  • Gao, P., Tchernyshyov, I., Chang, T.C. et al. (2009). c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458, 762765.
  • Govindarajan, B., Sligh, J.E., Vincent, B.J. et al. (2007). Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J. Clin. Invest. 117, 719729.
  • Hanahan, D., and Weinberg, R.A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646674.
  • Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A.L., Kafri, R., Kirschner, M.W., Clish, C.B., and Mootha, V.K. (2012). Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336, 10401044.
  • Janeway, K.A., Kim, S.Y., Lodish, M. et al. (2011). Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc. Natl. Acad. Sci. USA 108, 314318.
  • Koppenol, W.H., Bounds, P.L., and Dang, C.V. (2011). Otto Warburg’s contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 11, 325337.
  • Lemons, J.M., Feng, X.J., Bennett, B.D., Legesse-Miller, A., Johnson, E.L., Raitman, I., Pollina, E.A., Rabitz, H.A., Rabinowitz, J.D., and Coller, H.A. (2010). Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol. 8, e1000514.
  • Liu, W., Le, A., Hancock, C., Lane, A.N., Dang, C.V., Fan, T.W., and Phang, J.M. (2012). Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc. Natl. Acad. Sci. USA 109, 89838988.
  • Locasale, J.W., Grassian, A.R., Melman, T. et al. (2011). Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43, 869874.
  • Lopez, G.Y., Reitman, Z.J., Solomon, D., Waldman, T., Bigner, D.D., McLendon, R.E., Rosenberg, S.A., Samuels, Y., and Yan, H. (2010). IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem. Biophys. Res. Commun. 398, 585587.
  • Lu, C., Ward, P.S., Kapoor, G.S. et al. (2012). IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483, 474478.
  • Manca, A., Sini, M.C., Izzo, F. et al. (2011). Induction of arginosuccinate synthetase (ASS) expression affects the antiproliferative activity of arginine deiminase (ADI) in melanoma cells. Oncol. Rep. 25, 14951502.
  • Mazurek, S. (2011). Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int. J. Biochem. Cell Biol. 43, 969980.
  • Metallo, C.M., Gameiro, P.A., Bell, E.L. et al. (2012). Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481, 380384.
  • Mullarky, E., Mattaini, K.R., Vander Heiden, M.G., Cantley, L.C., and Locasale, J.W. (2011). PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell Melanoma Res. 24, 11121115.
  • Mullen, A.R., Wheaton, W.W., Jin, E.S., Chen, P.H., Sullivan, L.B., Cheng, T., Yang, Y., Linehan, W.M., Chandel, N.S., and DeBerardinis, R.J. (2012). Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481, 385388.
  • Parsons, D.W., Jones, S., Zhang, X. et al. (2008). An integrated genomic analysis of human glioblastoma multiforme. Science 321, 18071812.
  • Possemato, R., Marks, K.M., Shaul, Y.D. et al. (2011). Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346350.
  • Richardson, A.D., Yang, C., Osterman, A., and Smith, J.W. (2008). Central carbon metabolism in the progression of mammary carcinoma. Breast Cancer Res. Treat. 110, 297307.
  • Scott, D.A., Richardson, A.D., Filipp, F.V., Knutzen, C.A., Chiang, G.G., Ronai, Z.A., Osterman, A.L., and Smith, J.W. (2011). Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. J. Biol. Chem. 286, 4262642634.
  • Shibata, T., Kokubu, A., Miyamoto, M., Sasajima, Y., and Yamazaki, N. (2011). Mutant IDH1 confers an in vivo growth in a melanoma cell line with BRAF mutation. Am. J. Pathol. 178, 13951402.
  • Thornburg, J.M., Nelson, K.K., Clem, B.F., Lane, A.N., Arumugam, S., Simmons, A., Eaton, J.W., Telang, S., and Chesney, J. (2008). Targeting aspartate aminotransferase in breast cancer. Breast Cancer Res. 10, R84.
  • Tsai, W.B., Aiba, I., Long, Y., Lin, H.K., Feun, L., Savaraj, N., and Kuo, M.T. (2012). Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells. Cancer Res. 72, 26222633.
  • Turcan, S., Rohle, D., Goenka, A. et al. (2012). IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483, 479483.
  • Warburg, O. (1923). Versuche am überlebenden Karzinomgewebe. Biochem. Z. 142, 317333.
  • Ward, P.S., Patel, J., Wise, D.R. et al. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225234.
  • Wei, X., Walia, V., Lin, J.C. et al. (2011). Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Nat. Genet. 43, 442446.
  • Wise, D.R., DeBerardinis, R.J., Mancuso, A. et al. (2008). Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc. Natl. Acad. Sci. USA 105, 1878218787.
  • Wise, D.R., Ward, P.S., Shay, J.E., Cross, J.R., Gruber, J.J., Sachdeva, U.M., Platt, J.M., DeMatteo, R.G., Simon, M.C., and Thompson, C.B. (2011). Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability. Proc. Natl. Acad. Sci. USA 108, 1961119616.
  • Yang, C., Richardson, A.D., Smith, J.W., and Osterman, A. (2007). Comparative metabolomics of breast cancer. Pac. Symp. Biocomput., 18, 1192.
  • Yang, C., Richardson, A., Osterman, A., and Smith, J. (2008). Profiling of central metabolism in human cancer cells by two-dimensional NMR, GC-MS analysis, and isotopomer modeling. Metabolomics 4, 1329.
  • Yang, C., Sudderth, J., Dang, T., Bachoo, R.M., McDonald, J.G., and DeBerardinis, R.J. (2009). Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69, 79867993.
  • Zecchin, K.G., Alberici, L.C., Riccio, M.F., Eberlin, M.N., Vercesi, A.E., Graner, E., and Catharino, R.R. (2011). Visualizing inhibition of fatty acid synthase through mass spectrometric analysis of mitochondria from melanoma cells. Rapid Commun. Mass Spectrom. 25, 449452.