pcmr12069-sup-0001-Supplementary-material.docWord document2957K

Table S1. Characteristics of subjects in MD Anderson melanoma genome-wide association study (in 1957 subjects [931 cases and 1026 controls] who had questionnaire data).

Table S2. The summary of associations between tagSNPs in the M/G1 transition related cell cycle pathway and risk of melanoma in the MD Anderson melanoma GWAS (1804 melanoma cases and 1026 controls).

Table S3. All top hits (P < 0.01) of genetic variants in the M/G1 transition of cell cycle pathway and their associations with Melanoma risk based on data from the MD Anderson melanoma GWAS (1804 melanoma cases and 1026 controls).

Figure S1. The PSMB9 gene structure (A) on chromosome 6 and its LD plot (B) with the location of two SNPs rs135383 and rs2127675.

Figure S2. The PSMB9 mRNA expression in CEU (A, 84 cell lines) and unrelated populations (B, 201 cell lines of CEU, CHB/JPN and YRI) by the genotype of the promoter rs2071480 (in complete LD with rs1351383).

Figure S3. The PSMB9 mRNA expression in 7 normal skin, 18 benign nevi and 45 primary melanoma tissues (data extracted from Gene Expression Omnibus (GEO) at the NCBI.

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