Both authors contributed equally to the work.
Association between putative functional variants in the PSMB9 gene and risk of melanoma – re-analysis of published melanoma genome-wide association studies
Version of Record online: 27 MAR 2013
© 2013 John Wiley & Sons A/S
Pigment Cell & Melanoma Research
Volume 26, Issue 3, pages 392–401, May 2013
How to Cite
Qian, J., Liu, H., Wei, S., Liu, Z., Li, Y., Wang, L.-E., Chen, W. V., Amos, C. I., Lee, J. E., GenoMEL investigators, Iles, M. M., Law, M. H., Q-MEGA AMFS investigators, Cust, A. E., Barrett, J. H., Montgomery, G. W., Taylor, J., Bishop, J. A. N., MacGregor, S., Bishop, D. T., Mann, G. J., Hayward, N. K. and Wei, Q. (2013), Association between putative functional variants in the PSMB9 gene and risk of melanoma – re-analysis of published melanoma genome-wide association studies. Pigment Cell & Melanoma Research, 26: 392–401. doi: 10.1111/pcmr.12069
- Issue online: 19 APR 2013
- Version of Record online: 27 MAR 2013
- Accepted manuscript online: 29 JAN 2013 10:14AM EST
- Manuscript Accepted: 21 JAN 2013
- Manuscript Received: 18 JUL 2012
- National Institutes of Health. Grant Numbers: R01 CA100264, C588/A4994, C588/A10589, CC8216/A6129, CA88363, CA83115, CA122838, CA87969, CA055075, CA100264, CA133996, R01ES011740, CA49449, R01CA131274, P50 CA093459, P30 CA016672, HHSN268200782096C, P30 CA016672, LSHC-CT-2006-018702, CA83115
- National Health and Medical Research Council of Australia. Grant Numbers: 107359, 200071, 241944, 339462, 380385, 389927, 389875, 389891, 389892, 389938, 402761, 443036, 442915, 442981, 496610, 496675, 496739, 552485, 552498
- Cancer Councils NSW
- Cancer Institute New South Wales
- Cooperative Research Centre for Discovery of Genes for Common Human Diseases (CRC)
- Cerylid Biosciences
- Australian Cancer Research Foundation
- The Wellcome Trust. Grant Number: WT084766/Z/08/Z
- Marit Peterson Fund for Melanoma Research
- NHMRC Fellowships scheme
- Cancer Australia grant. Grant Numbers: C588/A4994, C588/A10589, CC8216/A6129, CA88363, CA83115, CA122838, CA87969, CA055075, CA100264, CA133996, CA49449, 107359, 200071, 241944, 339462, 380385, 389927, 389875, 389891, 389892, 389938, 402761, 443036, 442915, 442981, 496610, 496675, 496739, 552485, 552498, P50 CA093459, WT084766/Z/08/Z, P30 CA016672, HHSN268200782096C, P30 CA016672, LSHC-CT-2006-018702, CA83115
- UT MD Anderson Cancer Center SPORE. Grant Numbers: P50 CA093459, P30 CA016672
- M.D. Anderson Cancer Center. Grant Number: HHSN268200782096C
- Cancer Center Core Grant. Grant Number: P30 CA016672
- European Commission under the 6th Framework Programme. Grant Number: LSHC-CT-2006-018702
- National Cancer Institute (NCI)
- US National Institute of Health (NIH). Grant Number: CA83115
- Cancer Research UK. Grant Numbers: C588/A4994, C588/A10589, CC8216/A6129
- Melanoma Research Alliance, the National Institutes of Health/National Cancer Institute
Table S1. Characteristics of subjects in MD Anderson melanoma genome-wide association study (in 1957 subjects [931 cases and 1026 controls] who had questionnaire data).
Table S2. The summary of associations between tagSNPs in the M/G1 transition related cell cycle pathway and risk of melanoma in the MD Anderson melanoma GWAS (1804 melanoma cases and 1026 controls).
Table S3. All top hits (P < 0.01) of genetic variants in the M/G1 transition of cell cycle pathway and their associations with Melanoma risk based on data from the MD Anderson melanoma GWAS (1804 melanoma cases and 1026 controls).
Figure S1. The PSMB9 gene structure (A) on chromosome 6 and its LD plot (B) with the location of two SNPs rs135383 and rs2127675.
Figure S2. The PSMB9 mRNA expression in CEU (A, 84 cell lines) and unrelated populations (B, 201 cell lines of CEU, CHB/JPN and YRI) by the genotype of the promoter rs2071480 (in complete LD with rs1351383).
Figure S3. The PSMB9 mRNA expression in 7 normal skin, 18 benign nevi and 45 primary melanoma tissues (data extracted from Gene Expression Omnibus (GEO) at the NCBI.
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