Author's Note: Related work supporting the importance of MERTK in melanoma was recently reported by Schlegel et al. (J. Clin. Invest., Epub).
MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL
Article first published online: 21 MAY 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Pigment Cell & Melanoma Research
Volume 26, Issue 4, pages 527–541, July 2013
How to Cite
Tworkoski, K. A., Platt, J. T., Bacchiocchi, A., Bosenberg, M., Boggon, T. J. and Stern, D. F. (2013), MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL. Pigment Cell & Melanoma Research, 26: 527–541. doi: 10.1111/pcmr.12110
- Issue published online: 26 JUN 2013
- Article first published online: 21 MAY 2013
- Accepted manuscript online: 25 APR 2013 10:10AM EST
- Manuscript Accepted: 12 APR 2013
- Manuscript Received: 19 DEC 2012
- Yale SPORE in Skin Cancer. Grant Number: P50 CA121974
- Harry J Lloyd Charitable Trust
- National Science Foundation Graduate Research Fellowship
|pcmr12110-sup-0001-FigureS1.pdf||application/PDF||618K||Figure S1. AXL and MERTK are differentially expressed in melanoma and correlate with different gene expression patterns.|
|pcmr12110-sup-0002-FigureS2.pdf||application/PDF||4337K||Figure S2. MERTK expression increases during melanoma development, and targeting MERTK is detrimental to melanoma cells.|
|pcmr12110-sup-0003-FigureS3.pdf||application/PDF||1911K||Figure S3. Prolonged MERTK knockdown affects cell migration but not proliferation, survival, or AKT signaling.|
|pcmr12110-sup-0004-FigureS4.pdf||application/PDF||786K||Figure S4. Transfection of GFP and MERTK constructs into 293T cells.|
Table S1. AXL and MERTK expression in melanoma.
Table S2. Genes correlated with expression of TAM family members.
Table S3.AXL and MERTK are associated with different transcriptional signatures.
Table S4.Relative gene expression in AXL- and MERTK-positive cell lines.
Table S5. Pathways associated with AXL expression.
Table S6. Pathways associated with MERTK expression.
Table S7. MERTK regulates melanoma cell survival.
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