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Keywords:

  • angiotropism;
  • pericyticmimicry;
  • extravascular migratory metastasis (EVMM);
  • stem cell/embryonic migration;
  • abluminal vascular surface

Summary

We hypothesize that the interaction between angiotropic melanoma cells and the abluminal vascular surface can induce or sustain embryonic and/or stem cell migratory properties in these tumor cells. As a result, such angiotropic melanoma cells may migrate along the abluminal vascular surface, demonstrating pericytic mimicry. Through these cellular interactions, melanoma cells may migrate toward secondary sites.