Could pericytic mimicry represent another type of melanoma cell plasticity with embryonic properties?
Version of Record online: 27 JUN 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Pigment Cell & Melanoma Research
Volume 26, Issue 5, pages 746–754, September 2013
How to Cite
Lugassy, C., Péault, B., Wadehra, M., Kleinman, H. K. and Barnhill, R. L. (2013), Could pericytic mimicry represent another type of melanoma cell plasticity with embryonic properties?. Pigment Cell & Melanoma Research, 26: 746–754. doi: 10.1111/pcmr.12120
- Issue online: 23 AUG 2013
- Version of Record online: 27 JUN 2013
- Accepted manuscript online: 22 JUN 2013 07:01AM EST
- Manuscript Accepted: 22 MAY 2013
- Manuscript Received: 20 FEB 2013
- extravascular migratory metastasis (EVMM);
- stem cell/embryonic migration;
- abluminal vascular surface
We hypothesize that the interaction between angiotropic melanoma cells and the abluminal vascular surface can induce or sustain embryonic and/or stem cell migratory properties in these tumor cells. As a result, such angiotropic melanoma cells may migrate along the abluminal vascular surface, demonstrating pericytic mimicry. Through these cellular interactions, melanoma cells may migrate toward secondary sites.