These authors contributed equally to this work.
Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma
Version of Record online: 23 AUG 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Pigment Cell & Melanoma Research
Volume 26, Issue 6, pages 852–860, November 2013
How to Cite
Dutton-Regester, K., Kakavand, H., Aoude, L. G., Stark, M. S., Gartside, M. G., Johansson, P., O'Connor, L., Lanagan, C., Tembe, V., Pupo, G. M., Haydu, L. E., Schmidt, C. W., Mann, G. J., Thompson, J. F., Scolyer, R. A. and Hayward, N. K. (2013), Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma. Pigment Cell & Melanoma Research, 26: 852–860. doi: 10.1111/pcmr.12153
- Issue online: 24 OCT 2013
- Version of Record online: 23 AUG 2013
- Accepted manuscript online: 25 JUL 2013 03:25AM EST
- Manuscript Accepted: 19 JUL 2013
- Manuscript Received: 9 APR 2013
- Rio Tinto Ride
- National Health and Medical Research Council Fellowship
Table S1. Summary of samples exome sequenced and associated mutation status. 1: Data generated in this project. 2: Data from “Hodis et al., 2012;. A landscape of driver mutations in melanoma. Cell. 150(20):251-263”. 3: Data from “Krauthammer et al., 2012. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nature Genetics. 44(9):1006-1014”.
Table S2. Exome sequencing results from 32 MUP.
Table S3. Mutation rates of genes frequently mutated in melanoma from exome sequencing results. Comparison is between 32 MUP exomes and a cohort of 151 MKP taken from publications Krauthammer 2012 and Hodis 2012. Numbers and values are based on non-synonymous mutations only. NF1, CDKN2A and PTEN are mutated at a lower frequency in MUP than MKP- note: homozygous deletions of chromosomes are not taken into consideration
Table S4. Melanoma specific mutation panel results of MUP.
Table S5. Melanoma specific mutation panel results of MKP.
Table S6. Exome sequencing coverage statistics.
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