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Figure S1. Heat map of immune response genes overexpressed and underexpressed in melanoma cells as compared with autologous melanocyte cultures.

Figure S2. Immunohistochemistry showing HLA-E expression in normal melanocytes adjacent to some intradermal nevi.

Figure S3. Immunohistochemistry showing undetectable HLA-E expression in normal melanocytes from the intact, morphologically normal skin.

Figure S4. Cell surface HLA-E expression as detected by surface biotin labeling.

Figure S5. IL-2 enhances and de novo induces NK cell lysis of melanoma cells and melanocyte cultures, respectively.

Figure S6. The same cytotoxicity experiment shown in Figure 5.

Table S1. Top-ranking up-regulated and down-regulated immune genes in melanoma as compared with melanocyte cultures.

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