A melanoma immune response signature including Human Leukocyte Antigen-E
Article first published online: 9 OCT 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Pigment Cell & Melanoma Research
Volume 27, Issue 1, pages 103–112, January 2014
How to Cite
Tremante, E., Ginebri, A., Lo Monaco, E., Benassi, B., Frascione, P., Grammatico, P., Cappellacci, S., Catricalà, C., Arcelli, D., Natali, P. G., Di Filippo, F., Mottolese, M., Visca, P., Benevolo, M. and Giacomini, P. (2014), A melanoma immune response signature including Human Leukocyte Antigen-E. Pigment Cell & Melanoma Research, 27: 103–112. doi: 10.1111/pcmr.12164
- Issue published online: 18 DEC 2013
- Article first published online: 9 OCT 2013
- Accepted manuscript online: 7 SEP 2013 01:02AM EST
- Manuscript Accepted: 27 AUG 2013
- Manuscript Received: 28 SEP 2012
- Italian Ministry of Health
- Associazione Italiana Ricerca sul Cancro (AIRC)
Figure S1. Heat map of immune response genes overexpressed and underexpressed in melanoma cells as compared with autologous melanocyte cultures.
Figure S2. Immunohistochemistry showing HLA-E expression in normal melanocytes adjacent to some intradermal nevi.
Figure S3. Immunohistochemistry showing undetectable HLA-E expression in normal melanocytes from the intact, morphologically normal skin.
Figure S4. Cell surface HLA-E expression as detected by surface biotin labeling.
Figure S5. IL-2 enhances and de novo induces NK cell lysis of melanoma cells and melanocyte cultures, respectively.
Figure S6. The same cytotoxicity experiment shown in Figure 5.
Table S1. Top-ranking up-regulated and down-regulated immune genes in melanoma as compared with melanocyte cultures.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.