Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma
Version of Record online: 21 NOV 2013
© 2013 The Authors. Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Pigment Cell & Melanoma Research
Volume 27, Issue 1, pages 37–47, January 2014
How to Cite
Simpson, R. M., Bastian, B. C., Michael, H. T., Webster, J. D., Prasad, M. L., Conway, C. M., Prieto, V. M., Gary, J. M., Goldschmidt, M. H., Esplin, D. G., Smedley, R. C., Piris, A., Meuten, D. J., Kiupel, M., Lee, C.-C. R., Ward, J. M., Dwyer, J. E., Davis, B. J., Anver, M. R., Molinolo, A. A., Hoover, S. B., Rodriguez-Canales, J. and Hewitt, S. M. (2014), Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell & Melanoma Research, 27: 37–47. doi: 10.1111/pcmr.12185
- Issue online: 18 DEC 2013
- Version of Record online: 21 NOV 2013
- Accepted manuscript online: 15 OCT 2013 11:42AM EST
- Manuscript Accepted: 11 OCT 2013
- Manuscript Received: 13 AUG 2013
- Intramural Research Program, Center for Cancer Research, National Cancer Institute
- The Canine Comparative Oncology and Genomics Consortium, Inc.
- The Animal Cancer Foundation. Grant Numbers: R01- CA131524, P01 CA025874
- National Cancer Institute. Grant Number: HHSN261200800001E
- animal model;
- comparative study;
- clinical trial design;
- image analysis;
- digital telepathology;
- signal transduction
Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a more relevant preclinical model. Canine melanomas rarely arise in sun-exposed sites. Most occur in the oral cavity, with a subset having intra-epithelial malignant melanocytes mimicking the in situ component of human mucosal melanoma. The spectrum of canine melanocytic neoplasia includes benign lesions with some analogy to nevi, as well as invasive primary melanoma, and widespread metastasis. Growing evidence of distinct subtypes in humans, differing in somatic and predisposing germ-line genetic alterations, cell of origin, epidemiology, relationship to ultraviolet radiation and progression from benign to malignant tumors, may also exist in dogs. Canine and human mucosal melanomas appear to harbor BRAF, NRAS, and c-kit mutations uncommonly, compared with human cutaneous melanomas, although both species share AKT and MAPK signaling activation. We conclude that there is significant overlap in the clinical and histopathological features of canine and human mucosal melanomas. This represents opportunity to explore canine oral cavity melanoma as a preclinical model.