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Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes

Authors

  • Khaled Ezzedine,

    Corresponding author
    1. Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin and University of Bordeaux and Inserm U1035, Bordeaux, France
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  • Aurélie Le Thuaut,

    1. Université Paris Est Créteil (UPEC), LIC EA4393, Creteil, France
    2. Department of Public Health, hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France
    3. Unité de Recherche Clinique Mondor (URC), Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France
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  • Thomas Jouary,

    1. Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin and University of Bordeaux and Inserm U1035, Bordeaux, France
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  • Fabienne Ballanger,

    1. Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin and University of Bordeaux and Inserm U1035, Bordeaux, France
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  • Alain Taieb,

    1. Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin and University of Bordeaux and Inserm U1035, Bordeaux, France
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    • Part of this work has been presented as an oral communication at the Epidemiology and Health services research session of the 2013 International Investigative Dermatology meeting, Edinburgh, May 2013.
  • Sylvie Bastuji-Garin

    1. Université Paris Est Créteil (UPEC), LIC EA4393, Creteil, France
    2. Department of Public Health, hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France
    3. Unité de Recherche Clinique Mondor (URC), Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France
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    • Part of this work has been presented as an oral communication at the Epidemiology and Health services research session of the 2013 International Investigative Dermatology meeting, Edinburgh, May 2013.

  • These authors contributed equally to this work.

Summary

Non-segmental vitiligo (NSV) is an enigmatic disease with various clinical courses. To empirically identify underlying subtypes of NSV, we performed latent class analysis (LCA) of 717 consecutive patients with NSV seen between 2006 and 2012 and were analyzed. Median age was 32 yrs (14–45), median age at NSV onset was 18 yrs (8–32), and median NSV duration 5 yrs (0.75–78.5). A two-class model showed the best fit. Of the 717 patients, 280 (39%) belonged to LC1 and 437 (61%) to LC2. LC1 patients had high probabilities for early disease onset (<12 yrs), halo nevi, family history of premature hair greying, Koebner phenomenon, previous episodes of repigmentation, and family history of vitiligo. By contrast, LC2 patients were characterized by a late disease onset (after or at the age of 12 yrs, median age of 30 yrs) and acrofacial localization without any lesions on trunk or limbs. These two LCA classes (LC1, ‘prepubertal onset’; LC2, ‘post-pubertal onset’) may help refining results from genome-wide association studies (GWAS) and allow a more accurate genotype–phenotype correlation and help defining more directed treatment protocols.

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