Structural correlates of cognitive deficit and elevated gamma noise power in schizophrenia
Version of Record online: 8 DEC 2013
© 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 68, Issue 3, pages 206–215, March 2014
How to Cite
Suazo, V., Díez, Á., Montes, C. and Molina, V. (2014), Structural correlates of cognitive deficit and elevated gamma noise power in schizophrenia. Psychiatry and Clinical Neurosciences, 68: 206–215. doi: 10.1111/pcn.12120
- Issue online: 6 MAR 2014
- Version of Record online: 8 DEC 2013
- Manuscript Accepted: 10 SEP 2013
- Manuscript Revised: 5 AUG 2013
- Manuscript Received: 25 FEB 2013
- Fondo de Investigaciones Sanitarias (Instituto de Salud Carlos III). Grant Number: PI1102203
- Gerencia Regional de Salud de Castilla y León. Grant Number: 613/A/11
- University of Salamanca
- Santander Bank
- Consejería de Educación – Junta de Castilla y León
- European Social Fund. Grant Number: EDU/1486/2008
- Marie Curie Intra European Fellowship. Grant Number: 330156-CODIP
- gamma oscillations;
- noise power;
- working memory
The aim of this study was to assess the relation between cognition, gray matter (GM) volumes and gamma noise power (amount of background oscillatory activity in the gamma band) in schizophrenia.
We explored the relation between cognitive performance and regional GM volumes using voxel-based morphometry (VBM), in order to discover if the association between gamma noise power (an electroencephalography measurement of background activity in the gamma band) and cognition is observed through structural deficits related to the disease. Noise power, magnetic resonance imaging and cognitive assessments were obtained in 17 drug-free paranoid patients with schizophrenia and 13 healthy controls.
In comparison with controls, patients showed GM deficits at posterior cingulate (bilateral),left inferior parietal (supramarginal gyrus) and left inferior dorsolateral prefrontal regions. Patients exhibited a direct association between performance in working memory and right temporal (superior and inferior gyri) GM densities. They also displayed a negative association between right anterior cerebellum volume and gamma noise power at the frontal midline (Fz) site.
A structural deficit in the cerebellum may be involved in gamma activity disorganization in schizophrenia. Temporal structural deficits may relate to cognitive dysfunction in this illness.