Changes in PR and QTc intervals after switching from olanzapine to risperidone in patients with stable schizophrenia
Article first published online: 9 JAN 2014
© 2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 68, Issue 5, pages 353–356, May 2014
How to Cite
Suzuki, Y., Sugai, T., Ono, S., Sawamura, K., Fukui, N., Watanabe, J., Tsuneyama, N., Saito, M. and Someya, T. (2014), Changes in PR and QTc intervals after switching from olanzapine to risperidone in patients with stable schizophrenia. Psychiatry and Clinical Neurosciences, 68: 353–356. doi: 10.1111/pcn.12136
- Issue published online: 24 APR 2014
- Article first published online: 9 JAN 2014
- Manuscript Accepted: 28 OCT 2013
- Manuscript Revised: 16 SEP 2013
- Manuscript Received: 23 JUL 2013
- AV block;
- PR interval;
- QT interval;
We examined the difference between the effects of olanzapine (OLZ) and risperidone (RIS) on PR and QT intervals among patients with stable schizophrenia using a cohort analysis.
Twenty-one subjects treated with OLZ were enrolled in the study. Following baseline assessments, which included PR and QT intervals, OLZ was switched to RIS for each subject. The same parameters were evaluated following the switch to RIS.
All patients who had been treated with OLZ were successfully switched to RIS. In all patients, we observed a significant decrease in PR interval (t = 2.397, P = 0.029) and no change in either QTc or RR interval. In female patients, the QTc interval was significantly decreased (t = 3.495, P = 0.008) following the switch, while in male patients, the QTc interval did not change. No patients showed a PR interval of >200 ms or a QTc interval of >500 ms.
OLZ treatment has a greater prolonging effect on PR and QT intervals compared with RIS. Careful attention may need to be paid to the cardiac conduction system in addition to QT prolongation during OLZ treatment.