Authors with equal contributions.
L-3,4-Dihydroxy-6-[F-18]fluorophenylalanine positron emission tomography demonstrating dopaminergic system abnormality in the brains of obsessive–compulsive disorder patients
Version of Record online: 9 JAN 2014
© 2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society of Psychiatry and Neurology
Psychiatry and Clinical Neurosciences
Volume 68, Issue 4, pages 292–298, April 2014
How to Cite
Hsieh, H.-J., Lue, K.-H., Tsai, H.-C., Lee, C.-C., Chen, S.-Y. and Kao, P.-F. (2014), L-3,4-Dihydroxy-6-[F-18]fluorophenylalanine positron emission tomography demonstrating dopaminergic system abnormality in the brains of obsessive–compulsive disorder patients. Psychiatry and Clinical Neurosciences, 68: 292–298. doi: 10.1111/pcn.12139
- Issue online: 4 APR 2014
- Version of Record online: 9 JAN 2014
- Manuscript Accepted: 16 OCT 2013
- Manuscript Revised: 29 JUL 2013
- Manuscript Received: 9 JAN 2013
- Tzu-Chi General Hospital. Grant Number: TCRD 99-10
- obsessive–compulsive disorder;
- positron emission tomography
Obsessive–compulsive disorder (OCD) is a chronic disabling neuropsychiatric disorder. Current treatment modalities, such as pharmacological and behavioral methods, are sometimes unsatisfactory. The mesolimbic dopaminergic pathway is supposed to have a role in the pathogenesis of OCD. In this study, L-3,4-Dihydroxy-6-[F-18]fluorophenylalanine (F-18 FDOPA) positron emission tomography (PET) is exploited to investigate the possible abnormality of dopaminergic neuronal circuits in the brains of OCD patients in vivo.
The study subjects were recruited after psychological assessment and gave written informed consent to participate. The F-18 FDOPA PET scans were performed on five OCD patients and six healthy volunteers at 120 min after 185 MBq of F-18 FDOPA intravenous injection. The PET results were analyzed with the Statistical Parametric Mapping tool.
Compared to the healthy subjects, the OCD brains showed increased dopaminergic metabolism in the left frontal premotor cortex (P < 0.001), along with trends toward an increase in the left posterior cingulate gyrus, the left cuneus, the left lingual gyrus, the right cuneus and precuneus, the right lingual gyrus, the right middle temporal gyrus, the left cerebellum, and the right cerebellum (P < 0.01).
Our observations suggest that the increased dopaminergic neuronal function in these brain areas may be implicated in the pathogenesis of OCD.