Pediatric Primary Follicular Mucinosis: Further Evidence of its Relationship with Mycosis Fungoides

Authors

  • Angel Santos-Briz M.D., Ph.D.,

    Corresponding author
    1. Departamento de Anatomía Patológica, Hospital Universitario de Salamanca, Salamanca, Spain
    2. Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain
    • Address correspondence to Angel Santos-Briz, M.D., Ph.D., Departamento de Anatomía Patológica, Servicio de Dermatología, Hospital Universitario de Salamanca, Paseo San Vicente, 58-182, 37007, Salamanca, Spain, or e-mail: santosbriz@usal.es.

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  • Javier Cañueto M.D.,

    1. Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain
    2. Servicio de Dermatología, Hospital Universitario de Salamanca, Salamanca, Spain
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  • Jesus García-Dorado M.D.,

    1. Private practice, Salamanca, Spain
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  • M. Teresa Alonso M.D.,

    1. Servicio de Dermatología, Hospital Universitario de Salamanca, Salamanca, Spain
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  • Ana Balanzategui Bpharm,

    1. Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain
    2. Unidad de Genómica, Hospital Universitario de Salamanca, Salamanca, Spain
    3. Departamento de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain
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  • Marcos González-Díaz M.D., Ph.D.

    1. Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain
    2. Unidad de Genómica, Hospital Universitario de Salamanca, Salamanca, Spain
    3. Departamento de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain
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Abstract

Follicular mucinosis (FM) is an uncommon reaction pattern in which the accumulation of mucin in the follicular epithelium is the main pathologic finding. FM may be idiopathic (primary follicular mucinosis [PFM]), in association with mycosis fungoides or cutaneous T-cell lymphoma, or in association with other neoplastic and inflammatory conditions. Herein we report a case of PFM with identical T-cell clone rearrangement at anatomically distinct sites, supporting the idea that some authors have proposed, that FM may represent a low-grade lymphoproliferative disease related to mycoses fungoides with favorable prognosis.

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