A Review of Next-Generation Genetic Testing for the Dermatologist
Version of Record online: 28 DEC 2012
© 2012 Wiley Periodicals, Inc.
Volume 30, Issue 4, pages 401–408, July/August 2013
How to Cite
Kwon, E.-K. M., Basel, D., Siegel, D. and Martin, K. L. (2013), A Review of Next-Generation Genetic Testing for the Dermatologist. Pediatric Dermatology, 30: 401–408. doi: 10.1111/pde.12062
- Issue online: 2 JUL 2013
- Version of Record online: 28 DEC 2012
Dermatologists have been placed in a prime position to make new genetic discoveries. Tissue is easily obtained from the skin or mucosa for the study of germline and somatic mosaic disorders. This, along with the recent development of next-generation sequencing, makes dermatology an exciting field with essentially endless possibilities for discovering genes responsible for disease, better understanding complex molecular pathways, and eventually developing targeted therapies. To take advantage of this great opportunity, a basic understanding of the advances in genetic testing is vital. Herein we give an overview of next-generation sequencing, including some of the applications it may be used for. We also review various study designs for genetic discovery, each of their benefits and downfalls, and how they may be applied to the study of dermatologic disease.