A 10-week old preterm infant boy presented with a pustular eruption of the face and blood eosinophilia. Histology demonstrated eosinophils without predominant follicular involvement. The lesions healed without intervention within 2 months. The presentation was consistent with neonatal eosinophilic pustulosis. We discuss the similarities between cases described in the literature and suggest that this entity affects a unique patient population of preterm infants.