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A Case of Phrynoderma in a Patient with Crohn's Disease

Authors

  • Gabriela Cobos B.S.,

    1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
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  • Christine Cornejo B.S.,

    1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
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  • Patrick McMahon M.D.

    Corresponding author
    1. Section of Dermatology, Division of General Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    • Address correspondence to Patrick McMahon, M.D., Department of Pediatrics, Children's Hospital of Philadelphia, 3550 Market Street, 2nd Floor, Philadelphia, PA 19104, or e-mail: McMahonP@email.chop.edu.

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Abstract

Phrynoderma is a type of follicular hyperkeratosis associated with nutritional deficiencies. It is rarely seen in developed countries, although cases have been reported in patients with severe malnutrition or malabsorption secondary to various causes. This report describes a 19-year-old patient with poorly controlled Crohn's disease and malnutrition who developed the characteristic hyperkeratotic papules and plaques on his trunk and extremities in the setting of low serum vitamin A levels. To our knowledge, there are no reports of phrynoderma associated with Crohn's disease. It is likely that our patient's low vitamin A level and subsequent phrynoderma was the result of increased Crohn's disease activity and malnutrition.

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