Bullous Sweet's Syndrome After Granulocyte Colony-Stimulating Factor Therapy in a Child with Congenital Neutropenia

Authors

  • Oleg E. Akilov M.D., Ph.D.,

    1. Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania
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  • Nisha Desai M.D.,

    1. Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania
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  • Ronald Jaffe M.B.B.Ch.,

    1. Division of Pediatric Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania
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  • Robin P. Gehris M.D.

    Corresponding author
    1. Division of Pediatric Dermatology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • Address correspondence to Robin P. Gehris, M.D., Children's Dermatology Services, 11279 Perry Highway, Pine Center Suite 108, Wexford, PA 15090, or e-mail: gehrisrp@upmc.edu.

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Abstract

We present the case of a 20-month-old boy with congenital neutropenia for which he was being treated with granulocyte colony-stimulating factor (G-CSF) who developed bullous Sweet's syndrome. Because of the challenging and extensive differential diagnosis of an acute bullous eruption in an immunocompromised child, we highlight the importance of a prompt and precise diagnosis before initiation of any systemic therapy in children with Sweet's syndrome.

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