Effect of early measles vaccination (AIK-C strain) for preterm infants
Article first published online: 16 APR 2013
© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society
Volume 55, Issue 2, pages 163–168, April 2013
How to Cite
Ichikawa, T., Tsuji, A., Fujino, M., Kusano, R., Sugiyama, R., Oomori, S., Mori, K., Maeyama, K. and Nakayama, T. (2013), Effect of early measles vaccination (AIK-C strain) for preterm infants. Pediatrics International, 55: 163–168. doi: 10.1111/ped.12064
- Issue published online: 16 APR 2013
- Article first published online: 16 APR 2013
- Accepted manuscript online: 4 FEB 2013 11:56PM EST
- Manuscript Accepted: 6 NOV 2012
- Manuscript Revised: 22 AUG 2012
- Manuscript Received: 30 MAY 2012
- measles vaccination;
- neutralization test antibody;
- preterm infants
The level of maternal antibodies decreases more quickly in preterm than term infants, leaving them unprotected against measles. To protect premature infants from measles, an early vaccination trial was investigated.
Changes in the serum measles neutralization test (NT) antibody titer were examined in 152 infants (average gestational period, 29 weeks; average birthweight, 1203 g).
The average antibody titer (2n) was 23.5 at birth and 22.2 at 1–3 months of age, and in all cases, NT antibody titer decreased to <1:4 (150 IU/mL). The AIK-C measles vaccine was given to 17 preterm infants at the age of 6 months, and induced sufficient serological responses without any serious adverse events. NT antibody level did not decay during 12 months after vaccination.
Early immunization at 6 months of age is effective to protect preterm infants in the outbreak setting.