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Are metabolic syndrome antecedents in prepubertal children associated with being born idiopathic large for gestational age?

Authors

  • Ceren Çetin,

    1. Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
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  • Ahmet Uçar,

    Corresponding author
    1. Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
    • Corresponding author: Ahmet Uçar,

      Department of Paediatrics, Paediatric Endocrine Unit,

      Istanbul Faculty of Medicine, Istanbul University,

      Capa 34093, İstanbul,

      Turkey.

      Tel: +902124142000-31645;

      fax: +90-212-414-21-95;

      e-mail: aucar76@yahoo.com

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  • Firdevs Bas,

    1. Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
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  • Şükran Poyrazoğlu,

    1. Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
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  • Rüveyde Bundak,

    1. Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
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  • Nurçin Saka,

    1. Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
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  • Tülin Özden,

    1. Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
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  • Feyza Darendeliler

    1. Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
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Abstract

Introduction

Being born large for gestational age (LGA) is a risk factor for development of metabolic syndrome (MS) in adolescents and adults.

Objective

To evaluate prepubertal children born idiopathic LGA to non-obese mothers without gestational diabetes or glucosuria with respect to the presence of MS antecedents.

Patients and methods

We conducted a cross-sectional study to compare 40 (19 F) LGA-born prepubertal children of a mean age of 6.1 ± 2.5 yr and 49 (25 F) appropriate for gestational age (AGA)-born body mass index (BMI)-matched peers of a mean age of 5.4 ± 1.8 yr with respect to their anthropometric data, blood pressure measurements, fasting serum glucose and insulin levels, homeostasis model assessment-insulin resistance (HOMA-IR), and lipids and atherogenic index (AI) [triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)]. HOMA-IR > 2.5 was used to define IR. HDL-C ≤ 40 mg/dL and TG ≥ 110 mg/dL were used to define dyslipidemia. Both groups were further divided into subgroups as obese and non-obese according to their BMI percentiles and the analyses were repeated.

Results

Non-obese LGA children had higher waist circumference (WC) standard deviation scores (SDSs) than BMI-matched AGA-born peers (p = 0.024). There were no significant differences between pooled, obese and non-obese subgroups of LGA-born children and their AGA counterparts with respect to dyslipidemia and IR. AI was higher in non-obese LGA children than in AGA counterparts (p = 0.028).

Conclusions

Non-obese idiopathic LGA-born children have higher AIs than AGA-born counterparts in the absence of IR. WC seems to be a good clinical screening tool in identifying at risk of non-obese LGA children. Further studies are needed to evaluate MS antecedents in idiopathic LGA-born children.

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