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References

  • 1
    Pugliese A. The multiple origins of type 1 diabetes. Diabet Med 2013: 30: 135146.
  • 2
    Cizza G, Brown RJ, Rother KI. Rising incidence and challenges of childhood diabetes. A mini review. J Endocrinol Invest 2012: 35: 541546.
  • 3
    Herold KC, Vignali DA, Cooke A, Bluestone JA. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 2013: 13: 243256.
  • 4
    Rickels MR. Recovery of endocrine function after islet and pancreas transplantation. Curr Diab Rep 2012: 12: 587596.
  • 5
    Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 2005: 23: 447485.
  • 6
    Campbell-Thompson M, Wasserfall C, Kaddis J et al. Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes. Diabetes Metab Res Rev 2012: 28: 608617.
  • 7
    Campbell-Thompson ML, Montgomery EL, Foss RM et al. Collection protocol for human pancreas. J Vis Exp 2012: 63: e4039.
  • 8
    Campbell-Thompson ML, Heiple T, Montgomery E, Zhang L, Schneider L. Staining protocols for human pancreatic islets. J Vis Exp 2012: 63: e4068.
  • 9
    Rewers A. Current concepts and controversies in prevention and treatment of diabetic ketoacidosis in children. Curr Diab Rep 2012: 12: 524532.
  • 10
    Rosenbloom AL. The management of diabetic ketoacidosis in children. Diabetes Ther 2010: 1: 103120.
  • 11
    Burke GW III, Vendrame F, Pileggi A, Ciancio G, Reijonen H. Pugliese A. Curr Diab Rep: Recurrence of autoimmunity following pancreas transplantation, 2011: 1: 229238.
  • 12
    Liu EH, Digon BJ III, Hirshberg B et al. Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. Diabetologia 2009: 52: 13691380.
  • 13
    Stene LC, Oikarinen S, Hyoty H et al. Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes 2010: 59: 31743180.
  • 14
    Lempainen J, Tauriainen S, Vaarala O et al. Interaction of enterovirus infection and Cow's milk-based formula nutrition in type 1 diabetes-associated autoimmunity. Diabetes Metab Res Rev 2011: 15: 10.
  • 15
    Oikarinen S, Martiskainen M, Tauriainen S et al. Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes 2011: 60: 276279.
  • 16
    Tauriainen S, Oikarinen S, Oikarinen M, Hyoty H. Enteroviruses in the pathogenesis of type 1 diabetes. Semin Immunopathol 2011: 33: 4555.
  • 17
    Oikarinen M, Tauriainen S, Honkanen T et al. Detection of enteroviruses in the intestine of type 1 diabetic patients. Clin Exp Immunol 2008: 151: 7175.
  • 18
    Salminen KK, Vuorinen T, Oikarinen S et al. Isolation of enterovirus strains from children with preclinical type 1 diabetes. Diabet Med 2004: 21: 156164.
  • 19
    Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG. Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia 2011: 54: 24172420.
  • 20
    Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG. The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 2009: 52: 11431151.
  • 21
    Dotta F, Censini S, van Halteren AG et al. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci USA 2007: 104: 51155120.
  • 22
    Tracy S, Drescher KM, Chapman NM. Enteroviruses and type 1 diabetes. Diabetes Metab Res Rev 2011: 27: 820823.
  • 23
    Yip L, Su L, Sheng D et al. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol 2009: 10: 10261033.
  • 24
    Spencer J, Peakman M. Post-mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the beta cell. Clin Exp Immunol 2009: 155: 125127.
  • 25
    Gianani R, Campbell-Thompson M, Sarkar SA et al. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia 2010: 53: 690698.
  • 26
    Keenan HA, Sun JK, Levine J et al. Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes 2010: 59: 28462853.
  • 27
    Coppieters KT, Wiberg A, Amirian N, Kay TW, von Herrath MG. Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals. Diabetes Metab Res Rev 2011: 27: 746754.
  • 28
    Green-Mitchell SM, Cazares LH, Semmes OJ, Nadler JL, Nyalwidhe JO. On-tissue identification of insulin: in situ reduction coupled with mass spectrometry imaging. Proteomics Clin Appl 2011: 5 (7–8): 448453.
  • 29
    Coppieters KT, Dotta F, Amirian N et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med 2012: 209: 5160.
  • 30
    Evanko SP, Potter-Perigo S, Bollyky PL, Nepom GT, Wight TN. Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration. Matrix Biol 2012: 31: 90100.
  • 31
    Freeby M, Ichise M, Harris PE. Vesicular monoamine transporter, type 2 (vmat2) expression as it compares to insulin and pancreatic polypeptide in the head, body and tail of the human pancreas. Islets 2012: 4: 393397.
  • 32
    Campbell-Thompson M, Wasserfall C, Montgomery EL, Atkinson MA, Kaddis JS. Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes. JAMA 2012: 308: 23372339.
  • 33
    Gregg BE, Moore PC, Demozay D et al. Formation of a human beta-cell population within pancreatic islets is set early in life. J Clin Endocrinol Metab 2012: 97: 31973206.
  • 34
    Marhfour I, Lopez XM, Lefkaditis D et al. Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia 2012: 55: 24172420.
  • 35
    Dai C, Brissova M, Hang Y et al. Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia 2012: 55: 707718.
  • 36
    Sarkar SA, Lee CE, Victorino F et al. Expression and regulation of chemokines in murine and human type 1 diabetes. Diabetes 2012: 61: 436446.
  • 37
    Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG. Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia 2013: 56: 185193.
  • 38
    Taylor-Fishwick DA, Weaver JR, Grzesik W et al. Production and function of IL-12 in islets and beta cells. Diabetologia 2013: 56: 126135.
  • 39
    Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013: 62: 25952604.
  • 40
    Korpos E, Kadri N, Kappelhoff R et al. The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes 2013: 62: 531542.
  • 41
    Yip L, Creusot RJ, Pager CT, Sarnow P, Fathman CG. Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3. J Mol Cell Biol 2013: 5: 99110.
  • 42
    Chen J, Feigenbaum L, Awasthi P et al. Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Ralpha. Proc Natl Acad Sci USA 2013: 110: 1353413539.
  • 43
    Rowe P, Wasserfall C, Croker B et al. Increased complement activation in human type 1 diabetes pancreata. Diabetes Care 2013: 36: 38153817.
  • 44
    Gardner JM, Metzger TC, McMahon EJ et al. Extrathymic aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4 T cells. Immunity 2013: 13: 10.
  • 45
    In't Veld P, Lievens D, De Grijse J et al. Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 2007: 56: 24002404.
  • 46
    Orban T, Sosenko JM, Cuthbertson D et al. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009: 32: 22692274.
  • 47
    Greenbaum CJ, Beam CA, Boulware D et al. Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data. Diabetes 2012: 61: 20662073.
  • 48
    Pugliese A, Zeller M, Fernandez AJ et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997: 15: 293297.
  • 49
    Pugliese A, Brown D, Garza D et al. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J Clin Invest 2001: 107: 555564.
  • 50
    Gotter J, Brors B, Hergenhahn M, Kyewski B. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med 2004: 199: 155166.
  • 51
    Anderson MS, Venanzi ES, Klein L et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002: 298: 13951401.
  • 52
    Gardner JM, DeVoss JJ, Friedman RS et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 2008: 321: 843847.