Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control
Article first published online: 20 JAN 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 16, Issue 1, pages 48–57, February 2015
How to Cite
Nguyen, T., Obeid, J., Walker, R. G., Krause, M. P., Hawke, T. J., McAssey, K., Vandermeulen, J. and Timmons, B. W. (2015), Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control. Pediatric Diabetes, 16: 48–57. doi: 10.1111/pedi.12117
- Issue published online: 21 JAN 2015
- Article first published online: 20 JAN 2014
- Manuscript Accepted: 18 DEC 2013
- Manuscript Revised: 28 OCT 2013
- Manuscript Received: 23 JUL 2013
- Natural Sciences and Engineering Research Council of Canada
- CIHR New Investigator Salary Award
- glycemic control;
- muscle function;
- type 1 diabetes mellitus
Patients with type 1 diabetes mellitus (T1DM) may experience poor muscle health as a result of chronic hyperglycemia. Despite this, muscle function in children with T1DM with good or poor glycemic control has yet to be examined in detail.
To assess differences in muscle-related fitness variables in children with T1DM with good glycemic control (T1DM-G), as well as those with poor glycemic control (T1DM-P), and non-diabetic, healthy controls.
Eight children with T1DM-G [glycosylated hemoglobin (HbA1c) ≤ 7.5% for 9 months], eight children with T1DM-P (HbA1c ≥ 9.0% for 9 months), and eight healthy controls completed one exercise session.
Anaerobic and aerobic muscle functions were assessed with a maximal isometric grip strength test, a Wingate test, and an incremental continuous cycling test until exhaustion. Blood samples were collected at rest to determine HbA1c at the time of testing. Physical activity was monitored over 7 d using accelerometry.
Children with T1DM-P displayed lower peak oxygen consumption (VO2peak) values (mL/kg/min) compared to healthy controls (T1DM-P: 33.2 ± 5.6, controls: 43.5 ± 6.3, p < 0.01), while T1DM-G (43.5 ± 6.3) had values similar to controls and T1DM-P. There was a negative relationship between VO2peak and HbA1c% (r = −0.54, p < 0.01). All groups were similar in all other fitness variables. There were no group differences in physical activity variables.
Children with T1DM-G did not display signs of impaired muscle function, while children with T1DM-P have signs of altered aerobic muscle capacity.