Unusual presentations of BK virus infections in pediatric renal transplant recipients
Article first published online: 22 NOV 2012
© 2012 John Wiley & Sons A/S.
Volume 17, Issue 1, pages E9–E15, February 2013
How to Cite
Unusual presentations of BK virus infections in pediatric renal transplant recipients., , , .
- Issue published online: 22 JAN 2013
- Article first published online: 22 NOV 2012
- Manuscript Accepted: 12 SEP 2012
- renal transplant;
- BK virus;
- BKV nephropathy;
- hemorrhagic cystitis
BKV has emerged as a significant pathogen in the field of transplantation, predominantly causing BKV nephropathy in renal transplant recipients and hemorrhagic cystitis in HSCT recipients. However, case reports describe more diverse complications, and we too present three unusual cases of BKV infections in pediatric renal transplant recipients. First, we describe a case of biopsy-proven renal damage secondary to BKV prior to the onset of viremia, demonstrating that BKV nephropathy can occur without preceding viremia. We also present two renal transplant recipients with persistent BK viruria, one with BKV-associated hemorrhagic cystitis and the other with microscopic hematuria. Therefore, we conclude that BKV manifestations may be more diverse than previously thought and suggest clinical utility in urine BKV qPCR testing in specific transplant recipients.