Results of single-center screening for chronic hepatitis E in children after liver transplantation and report on successful treatment with ribavirin
Article first published online: 3 APR 2013
© 2013 John Wiley & Sons A/S.
Volume 17, Issue 4, pages 343–347, June 2013
How to Cite
Results of single-center screening for chronic hepatitis E in children after liver transplantation and report on successful treatment with ribavirin, , , , , , .
- Issue published online: 20 MAY 2013
- Article first published online: 3 APR 2013
- Manuscript Accepted: 28 FEB 2013
- pediatric liver transplantation;
- hepatitis E virus;
- PCR ;
- graft function
RNA screening for HEV in 22 liver-transplanted children with chronic graft hepatitis out of a cohort of 267 liver-transplanted children detected a single patient with chronic HEV infection. Although this patient remained viremic for 33 months, anti-HEV-IgG was not detectable with MP assay but with Wantai assay. We present the first case of successful ribavirin therapy in an immunosuppressed child with chronic HEV infection. In conclusion, chronic HEV infection in immunosuppressed children may not be detectable employing serological assays. Therefore, the most reliably screening method is screening for HEV-RNA. Chronic HEV infection in children can successfully be treated with ribavirin.