Photoprotecting Action and Phytochemical Analysis of a Multiple Radical Scavenger Lipophilic Fraction Obtained from the Leaf of the Seagrass Thalassia testudinum (pages 1058–1066)
Erik L. Regalado, María Rodríguez, Roberto Menéndez, Xavier Fernandez, Ivones Hernández, Ruth A. Morales, Miguel D. Fernández, Olivier P. Thomas, Jorge A. Pino, Ángel R. Concepción and Abilio Laguna
Version of Record online: 7 JUL 2011 | DOI: 10.1111/j.1751-1097.2011.00945.x
The lipophilic fraction F1 obtained from Thalassia testudinum mainly composed of benzene derivatives, strongly scavenged DPPH˙, HO˙, RO2˙ and O2˙−; markedly inhibited the spontaneous lipid peroxidation in brain homogenates and the LPS-stimulated nitrite generation on RAW624.7 macrophages. In agreement with these findings, its topical application strikingly reduced skin damage on mice exposed to acute UVB radiation and significantly attenuated the lipid peroxidation in vivo after acute exposure to UVB irradiation. This suggests that the antioxidant activity of F1 partially accounted for its skin protective action.