Infrared (810 nm) Low-level Laser Therapy in Rat Achilles Tendinitis: A Consistent Alternative to Drugs (pages 1447–1452)
Rodrigo Labat Marcos, Ernesto Cesar Pinto Leal Junior, Felipe de Moura Messias, Maria Helena Catelli de Carvalho, Rodney Capp Pallotta, Lúcio Frigo, Rosângela Aparecida dos Santos, Luciano Ramos, Simone Teixeira, Jan Magnus Bjordal and Rodrigo Álvaro Brandão Lopes-Martins
Version of Record online: 7 OCT 2011 | DOI: 10.1111/j.1751-1097.2011.00999.x
We investigated if low-level laser therapy (LLLT) could reduce tendinitis inflammation, and whether a possible pathway could be through inhibition of either of the two-cyclooxygenase (COX) isoforms in inflammation. LLLT-dose of 3 J significantly reduced inflammation through less COX-2-derived gene expression and PGE2 production, and less edema compared to controls. Diclofenac exhibited significantly lower PGE2 cytokine levels than collagenase group, but COX isoform 1-derived gene expression and cytokine PGE2 levels were not affected by treatments. LLLT seems to act on inflammation through a selective inhibition of the COX-2. LLLT may have potential to become a new and safer nondrug alternative to coxibs.