Expression and Function of Macrophage Migration Inhibitory Factor in the Pathogenesis of UV-Induced Cutaneous Nonmelanoma Skin Cancer (pages 1157–1164)
Ruth Heise, Claudia S. Vetter-Kauczok, Claudia Skazik, Katharina Czaja, Yvonne Marquardt, Hongqi Lue, Hans F. Merk, Jürgen Bernhagen and Jens M. Baron
Article first published online: 8 MAR 2012 | DOI: 10.1111/j.1751-1097.2012.01108.x
Skin exposure to ultraviolet light stimulates the production of cytokines known to be involved in the initiation of skin cancer. Immunohistochemical analysis revealed an enhanced expression of macrophage migration inhibitory factor (MIF) in lesional skin of patients with UV-induced actinic keratosis or cutaneous squamous cell carcinoma (SCC). ELISA studies showed a time-dependent increase in MIF secretion after a single-dose UVB irradiation in NHEK and SCC tumor cells. MIF receptor CD74 is not constitutively expressed in keratinocytes but stimulation with IFNγ upregulated CD74 surface expression. These findings indicate that MIF may be an important factor in the pathogenesis of NMSC tumorigenesis.