Substituent Effect on the Photolability of 4-Aryl-1,4-Dihydropyridines (pages 73–78)
Cristóbal García, Karina Cabezas, Santi Nonell, Luis J. Núñez-Vergara, Javier Morales, Germán Günther and Nancy Pizarro
Article first published online: 30 OCT 2013 | DOI: 10.1111/php.12178
The electronic nature of substituents attached to the 4-aryl moiety of 1,4-dihydropyridines strongly affect the photophysical and photochemical behavior of these family of compounds. The presence of an electron-donor substituent on the 4-aryl moiety (or the absence of electron-withdrawing ones), diminishes the photodecomposition quantum yields. Studies in micellar media allow us to conclude that 4-aryl-1,4-dihydropyridines are located near to the interface, however the surface charge of micelles has no effect on the photodegradation rate constant or the photoproducts profile. Our main conclusion is that the photolability of 4-aryl-1,4-dihydropyridines can be significantly reduced by the incorporation of antioxidant moieties.