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The effect of ultraviolet radiation from a novel portable fluorescent lamp on serum 25-hydroxyvitamin D3 levels in healthy adults with Fitzpatrick skin types II and III

Authors

  • Nicholas S. Dabai,

    1. Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, USA
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  • Pornpoj Pramyothin,

    1. Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, USA
    2. Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
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  • Michael F. Holick

    Corresponding author
    • Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, USA
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  • Conflicts of interest:

    The authors received equipment and other support from KBD, Inc the manufacturer of the Sperti D/UV-Fluorescent lamp as part of the R43AG030246 collaboration.

Correspondence:

Dr Michael F. Holick, M.D., Ph.D., Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 85 East Newton St, M-1013, Boston, MA 02118, USA.

Fax: +1 617 638 8882

Tel: +1 617 638 4546

e-mail: mfholick@bu.edu

Summary

Background/Purpose

Ultraviolet (UV) B irradiation may provide a safe and effective method to treat vitamin D deficiency. The objective of this study was to assess the effectiveness of a novel Sperti D/UV-Fluorescent lamp in converting 7-dehydrocholesterol (7-DHC) to previtamin D3 in vitro and in raising serum 25-hydroxyvitamin D3 [25(OH)D3] in healthy adults.

Methods

The lamp was assessed in vitro using a 7-DHC solution and a human skin sample. In a prospective cohort study, five healthy adults with skin types II and III were exposed to a 0.75 minimal erythemal dose of UV radiation over ∼9% of body surface area three times a week for 4 weeks. The main outcomes were percentage of conversion from 7-DHC to previtamin D3 in vitro and changes in serum 25(OH)D3 after irradiation in vivo.

Results

A dose response between UV irradiation time and conversion of 7-DHC to previtamin D3 was seen in the 7-DHC solution and surgically obtained human skin. The subjects had a significant increase in mean 25(OH)D3 from 18.4 ± 8.2 to 27.3 ± 7.6 ng/ml (P < 0.001) after 4 weeks of irradiation. No adverse events occurred.

Conclusion

The Sperti D/UV-Fluorescent lamp is effective in converting 7-DHC to previtamin D3 in vitro and in raising serum 25(OH)D3 in healthy adults.

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