Conflicts of interest:
Psoriasis treatment: faster and long-standing results after bathing in geothermal seawater. A randomized trial of three UVB phototherapy regimens
Version of Record online: 10 DEC 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Photodermatology, Photoimmunology & Photomedicine
Volume 30, Issue 1, pages 25–34, February 2014
How to Cite
Eysteinsdóttir, J. H., Ólafsson, J. H., Agnarsson, B. A., Lúðvíksson, B. R. and Sigurgeirsson, B. (2014), Psoriasis treatment: faster and long-standing results after bathing in geothermal seawater. A randomized trial of three UVB phototherapy regimens. Photodermatology, Photoimmunology & Photomedicine, 30: 25–34. doi: 10.1111/phpp.12090
This study was primarily sponsored by the Icelandic Technology Development Fund and the Landspitali University Hospital Research Fund. The Blue Lagoon Ltd. offered the treatment and the ensuing expenses free of charge.
- Issue online: 7 JAN 2014
- Version of Record online: 10 DEC 2013
- Accepted manuscript online: 20 NOV 2013 10:29PM EST
- Manuscript Accepted: 15 NOV 2013
- Landspitali University Hospital Research Fund
- Icelandic Technology Development Research Fund
- Blue Lagoon Ltd
- Blue Lagoon;
- geothermal seawater;
- histological score;
- quality of life
The combination of seawater baths and narrowband ultraviolet B (NB-UVB) is a known treatment for psoriasis. This study evaluates two treatment regimens that combine bathing in geothermal seawater and NB-UVB therapy in comparison with NB-UVB monotherapy.
Sixty-eight psoriasis patients were randomly assigned to outpatient bathing in geothermal seawater combined with NB-UVB therapy three times a week, intensive daily treatment involving bathing in geothermal seawater combined with NB-UVB therapy, or NB-UVB therapy alone three times a week; treatment period was 6 weeks. Disease severity [Psoriasis Area Severity Index (PASI) and Lattice System Physician's Global Assessment scores], quality of life (Dermatology Life Quality Index) and histological changes were evaluated before, during and after treatment. The primary end point was the proportion of patients who achieved PASI 75 at 6 weeks.
At 6 weeks, the percentage of patients who achieved PASI 75 and PASI 90 was significantly greater for both regimens, bathing in geothermal seawater three times a week (68.1% and 18.2%, respectively) and intensive treatment with geothermal seawater (73.1% and 42.3%, respectively) than for NB-UVB monotherapy (16.7% and 0%, respectively) (P < 0.05 in all comparisons). Clinical improvement was paralleled by improvement in quality of life and histological score and a reduction in NB-UVB doses.
Bathing in geothermal seawater combined with NB-UVB therapy in psoriasis induces faster clinical and histological improvement, produces longer remission time and permits lower NB-UVB doses than UVB therapy alone.