Both authors contributed equally to this work and share first authorship.
Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients
Article first published online: 6 JAN 2014
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Photodermatology, Photoimmunology & Photomedicine
Volume 30, Issue 5, pages 246–253, October 2014
How to Cite
Liu, L.-H., Fan, X., An, Y.-X., Zhang, J., Wang, C.-M. and Yang, R.-Y. (2014), Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients. Photodermatology, Photoimmunology & Photomedicine, 30: 246–253. doi: 10.1111/phpp.12098
Conflicts of interest:
- Issue published online: 16 SEP 2014
- Article first published online: 6 JAN 2014
- Accepted manuscript online: 9 DEC 2013 05:41AM EST
- Manuscript Accepted: 3 DEC 2013
- Foundation of Capital Medical Development and Research. Grant Number: 2007–3027
- Second Five-Year Plan of Military Medical Science and Technology Research Foundation. Grant Number: CWS11J218
- acne vulgaris;
- intense pulsed light;
- light-emitting diode;
- photodynamic therapy
Background and Aims
Acne vulgaris is common in Asian populations. We compared three methods of phototherapy for the treatment of moderate to severe facial acne vulgaris in Chinese patients.
Patients were randomly assigned to receive photodynamic therapy (PDT), intense pulsed light (IPL) or blue–red light-emitting diode (LED) phototherapy to the right side of the face until the inflammatory lesion count reduced by ≥ 90%. Patients were examined at 1 and 3 months after the final treatment.
We enrolled 150 patients (92 males; mean age, 28 years). At 1 month, ≥90% clearance or moderate improvement occurred in 46/50 (92%), 29/50 (58%) and 22/50 (44%) patients in the PDT, IPL and LED groups, respectively (mean number of sessions required, PDT: 3 ± 1.52; IPL: 6 ± 2.15; LED: 9 ± 3.34). Forty-six (92%) patients experienced mild to moderate pain, erythema and edema after PDT, which resolved within 5–7 days. Slight erythema and stinging were reported immediately after IPL and LED, resolving within 2 h. After 3 months, minimal papules and pustules were observed in 4 patients in the PDT group, 7 in the IPL group and 12 in the LED group, but no nodular pustules recurred.
Phototherapy is efficacious for moderate to severe facial acne vulgaris.