Get access

Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients

Authors

  • Li-Hong Liu,

    1. Department of Dermatology, General Hospital of Beijing Military Region of PLA, Beijing, China
    Search for more papers by this author
    • Both authors contributed equally to this work and share first authorship.
  • Xin Fan,

    1. Department of Dermatology, General Hospital of Beijing Military Region of PLA, Beijing, China
    Search for more papers by this author
    • Both authors contributed equally to this work and share first authorship.
  • Yu-Xi An,

    1. Department of Dermatology, General Hospital of Beijing Military Region of PLA, Beijing, China
    Search for more papers by this author
  • Jin Zhang,

    1. Department of Dermatology, General Hospital of Beijing Military Region of PLA, Beijing, China
    Search for more papers by this author
  • Cong-Min Wang,

    1. Department of Dermatology, General Hospital of Beijing Military Region of PLA, Beijing, China
    Search for more papers by this author
  • Rong-Ya Yang

    Corresponding author
    1. Department of Dermatology, General Hospital of Beijing Military Region of PLA, Beijing, China
    • Correspondence:

      Dr Rong-Ya Yang, MD, PhD, Department of Dermatology, General Hospital of Beijing Military Region of PLA, Beijing 100125, China.

      Tel: +86 13366927967

      Fax: +86 10-84008103

      e-mail: liulihongzjk@sina.com

    Search for more papers by this author

  • Conflicts of interest:

    None declared.

Summary

Background and Aims

Acne vulgaris is common in Asian populations. We compared three methods of phototherapy for the treatment of moderate to severe facial acne vulgaris in Chinese patients.

Methods

Patients were randomly assigned to receive photodynamic therapy (PDT), intense pulsed light (IPL) or blue–red light-emitting diode (LED) phototherapy to the right side of the face until the inflammatory lesion count reduced by ≥ 90%. Patients were examined at 1 and 3 months after the final treatment.

Results

We enrolled 150 patients (92 males; mean age, 28 years). At 1 month, ≥90% clearance or moderate improvement occurred in 46/50 (92%), 29/50 (58%) and 22/50 (44%) patients in the PDT, IPL and LED groups, respectively (mean number of sessions required, PDT: 3 ± 1.52; IPL: 6 ± 2.15; LED: 9 ± 3.34). Forty-six (92%) patients experienced mild to moderate pain, erythema and edema after PDT, which resolved within 5–7 days. Slight erythema and stinging were reported immediately after IPL and LED, resolving within 2 h. After 3 months, minimal papules and pustules were observed in 4 patients in the PDT group, 7 in the IPL group and 12 in the LED group, but no nodular pustules recurred.

Conclusions

Phototherapy is efficacious for moderate to severe facial acne vulgaris.

Ancillary