Conflicts of interest:
Effect of narrow band-ultraviolet B on CD4+ CD25high FoxP3+T-lymphocytes in the peripheral blood of vitiligo patients
Version of Record online: 23 JAN 2014
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Photodermatology, Photoimmunology & Photomedicine
Volume 30, Issue 5, pages 254–261, October 2014
How to Cite
Moftah, N. H., El-Barbary, R. A. H., Ismail, M. A. and Ali, N. A. M. (2014), Effect of narrow band-ultraviolet B on CD4+ CD25high FoxP3+T-lymphocytes in the peripheral blood of vitiligo patients. Photodermatology, Photoimmunology & Photomedicine, 30: 254–261. doi: 10.1111/phpp.12104
- Issue online: 16 SEP 2014
- Version of Record online: 23 JAN 2014
- Accepted manuscript online: 23 DEC 2013 04:32AM EST
- Manuscript Accepted: 15 DEC 2013
It is widely believed that an imbalance between activated CD8+T cells and regulatory T cells (Tregs) exists in patients with vitiligo. Although there is evidence that narrow band ultraviolet (NB-UVB) irradiation can induce Tregs' number and activity, but up to our knowledge, none of the published studies involved the possible effect of NB-UVB on Tregs in vitiligo.
To evaluate the effect of NB-UVB on circulating CD4+CD25highFoxP3+regulatory T cells (FoxP3+Tregs) in vitiligo.
This prospective analytic study included 20 patients with active non-segmental vitiligo and 20 healthy controls. The patients were exposed to NB-UVB therapy three times per week for 30 sessions. Blood sampling before and after NB-UVB phototherapy was done to evaluate circulating CD4+CD25highTregs and Foxp3+Tregs.
The CD4+CD25highTregs% and FoxP3+Tregs% were significantly higher in vitiligo patients compared with controls. NB-UVB therapy decreased both of them in patients, but they did not reach those of controls. Each of circulating CD4+CD25highTregs% and FoxP3+Tregs% didn't correlate with either extent or activity of vitiligo before or after NB-UVB.
Tregs functional defect is probably having an impact on NSV. NB-UVB may improve the function of Tregs. Understanding the mechanisms through which NB-UVB exert its effect on reducing the number of circulating Tregs would help open up the paths for future therapeutic options.