Fascin expression is related to poor survival in gastric cancer
Article first published online: 16 DEC 2012
© 2012 The Authors. Pathology International © 2012 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd
Volume 62, Issue 12, pages 777–784, December 2012
How to Cite
Kim, S. J., Kim, D. C., Kim, M. C., Jung, G. J., Kim, K. H., Jang, J. S., Kwon, H. C., Kim, Y. M. and Jeong, J. S. (2012), Fascin expression is related to poor survival in gastric cancer. Pathology International, 62: 777–784. doi: 10.1111/pin.12012
- Issue published online: 16 DEC 2012
- Article first published online: 16 DEC 2012
- Received 28 February 2012. Accepted for publication 29 October 2012.
- gastric cancer;
Fascin is an actin-binding protein that provides mechanical support and cell motility, and involves cancer cell metastasis. We investigated fascin protein expression in gastric cancer and assessed their relationship with clinicopathologic parameters and survival rates. In addition, we researched galectin-3 protein expression to study fascin action mechanisms. We performed immunohistochemisty with fascin and galectin-3 antibodies in 471 gastric carcinomas, using tissue microarrays. Fascin was positive in 14.9% (70/471) of the samples, and fascin expression was related to worse survival rates (P < 0.001), high clinical stage (P < 0.001), high T stage (P < 0.001), nodal metastasis (P < 0.001), lymphovascular invasion (P= 0.001) and the intestinal type of Lauren classification (P= 0.015). Galectin-3 protein expression was positive in 83.9% (395/471) of the samples and was reversely correlated with fascin protein expression (P= 0.020). Galectin-3 expression was related to low clinical stage (P < 0.001), but not to survival rates in multivariate analysis. In multivariate analysis, fascin expression was related to worse survival rates (HR = 1.56, P= 0.036), and can be an independent poor prognostic factor in gastric cancer.