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Figure S1. Kaplan–Meier disease-free survival curves by the 2011 IASLC/ATS/ERS classification system and modified histological grades for stage I lung adenocarcinomas (acinar-subdivided version). Five-year disease-free survival rates were calculated from the curves: (A) Acinar predominant subtype was sub-divided into single (SACN) and poly-layer (including cribriform) predominant (PACN) types; SACN, 96.6%; PACN, 67.1% (P = 0.0087). Patients with PACN demonstrated a poor DFS similar to those of the high-grade subtypes. (B) Modified histological grades. Tumors with PACN were categorized into the high-histological grade; low-grade (AIS, MIA), 100.0%; intermediate-grade (LEP, SACN, PAP), 91.5%; high-grade (PACN, MPAP, SOL, MUC), 59.6% (P < 0.0001).

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Table S1. Univariate analysis of disease-free survival in the acinar sub-divided version

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Table S2. Multivariate analysis of disease-free survival in the acinar-subdivided version

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