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Original Article
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Morphophenotype of floating colonies derived from a single cancer cell has a critical impact on tumor-forming activity
Article first published online: 7 JAN 2013
DOI: 10.1111/pin.12018
© 2012 The Authors. Pathology International © 2012 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd
Additional Information
How to Cite
Ishii, G., Hashimoto, H., Atsumi, N., Hoshino, A. and Ochiai, A. (2013), Morphophenotype of floating colonies derived from a single cancer cell has a critical impact on tumor-forming activity. Pathology International, 63: 29–36. doi: 10.1111/pin.12018
Publication History
- Issue published online: 29 JAN 2013
- Article first published online: 7 JAN 2013
- Manuscript Accepted: 19 NOV 2012
- Manuscript Received: 21 AUG 2012
Funded by
- Foundation for the Promotion of Cancer Research
- 3rd-Term Comprehensive 10-Year Strategy for Cancer Control
- National Cancer Center Research and Development Fund. Grant Number: 23-A-12
- JSPS KAKENHI. Grant Number: 20590417, 215981
References
- 1, , , . Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc Natl Acad Sci USA 1975; 72: 4435–4439.
- 2, . Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma. Proc Natl Acad Sci USA 1980; 77: 1039–1043.
- 3, , , , , . Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites. J Natl Cancer Inst 1989; 81: 1406–1412.
- 4, , , , , . Correlation of growth capacity of cells in hard agarose with successful transfection by the activated c-Ha-ras oncogene and in vivo proliferative capacity at metastatic sites. Anticancer Res 1991; 11: 17–24.
- 5, , et al. Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene 2009; 28: 2796–2805.
- 6, , et al. Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis. Cancer Sci 2012; 103: 1342–1347.
- 7, , et al. p53 modulation of anchorage independent growth and experimental metastasis. Oncogene 1996; 13: 1709–1719.
- 8, , et al. Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer. Cancer Res 2002; 62: 2971–2975.
- 9, , et al. Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar. Am J Pathol 2011; 178: 2357–2366.
- 10, . Invasive front of colorectal cancer: Dynamic interface of pro-/anti-tumor factors. World J Gastroenterol 2009; 15: 5898–5906.
- 11, , et al. Histopathologic features of the tumor budding in adenocarcinoma of the lung: Tumor budding as an index to predict the potential aggressiveness. J Thorac Oncol 2010; 5: 1361–1368.
- 12, , et al. Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 2001; 61: 4222–4228.
- 13, , . Carcinoma invasion and metastasis: A role for epithelial-mesenchymal transition? Cancer Res 2005; 65: 5991–5995.
- 14, et al. Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res 2008; 68: 937–945.
- 15, . Epithelial-mesenchymal transition: A cancer researcher's conceptual friend and foe. Am J Pathol 2009; 174: 1588–1593.
- 16, . Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9: 265–273.
- 17, , et al. Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation. Int J Cancer 2011; 128: 1585–1595.
- 18, , . Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation. Mol Cancer Res 2011; 9: 1608–1620.
- 19, , , , . TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 2005; 9: 56.
- 20, , et al. TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells. J Biochem 2012; 151: 205–216.
- 21, , et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A 2003; 100: 15178–15183.
- 22, , et al. Novel method for the isolation and characterisation of the putative prostatic stem cell. Cytometry A 2003; 54: 89–99.
- 23, , , , . Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A 2007; 104: 181–186.
- 24, , et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 2008; 15: 504–514.
- 25, , , , . Both CD133+ and CD133- subpopulations of A549 and H446 cells contain cancer-initiating cells. Cancer Sci 2009; 100: 1040–1046.
- 26, , et al. Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: A novel character of tumor educated fibroblasts. Int J Oncol 2010; 37: 317–325.