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pin12018-sup-0001-fig1.tif64K

Figure S1. The relationship between colony size and number of cells in type A and type B colonies. Left: The relationship between colony size and number of cells in type A. Right: The relationship between colony size and number of cells in type B. Note that the Type A colonies contained a larger number of cancer cells than Type B colonies of a comparable size.

pin12018-sup-0002-fig2.tif58K

Figure S2. Distribution of the number of cells per colony. Distribution of the number of cells per Type A and Type B colonies in Group 1 (0–1 × 104/colony): the mean numbers of cells per Type A and Type B colonies were 0.3 × 104 and 0.2 × 10,[4] respectively. No significant difference was observed. Distribution of the number of cells per Type A and Type B colonies in Group 2 (1–5 × 104/colony): the mean numbers of cells per Type A and Type B colonies were 2.2 × 104 and 2.7 × 10,[4] respectively. No significant difference was observed. Distribution of the number of cells per Type A and Type B colonies in Group 3 (5–10 × 104/colony): the mean numbers of cells per Type A and Type B colonies were 5.8 × 104 and 5.7 × 10,[4] respectively. No significant difference was observed.

Distribution of the number of cells per Type A colony in Group 4 (10- × 104/colony): the mean number of cells per Type A colony was 16.8 × 10.[4]

pin12018-sup-0003-fig3.tif60K

Figure S3. mRNA expression in A549 cells and fibroblasts. Left: EGF mRNA expression in A549 cells and fibroblasts. The relative EGF expression level was significantly higher in the A549 cells than in the fibroblasts (P = 0.03). Right: HGF mRNA expression in A549 cells and fibroblasts. HGF expression was only observed in the fibroblasts. The fibroblasts were obtained from human lung tissues and were cultured as previously reported.[26]

pin12018-sup-0004-table.tif101K

Table S1. Primer pairs used in this study.

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