Disclosure/Conflict of interest: The author declares that no conflicts of interest exist concerning the present article.
Granuloma cells in chronic inflammation express CD205 (DEC205) antigen and harbor proliferating T lymphocytes: Similarity to antigen-presenting cells
Article first published online: 22 FEB 2013
© 2013 The Author. Pathology International © 2013 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd
Volume 63, Issue 2, pages 85–93, February 2013
How to Cite
Ohtani, H. (2013), Granuloma cells in chronic inflammation express CD205 (DEC205) antigen and harbor proliferating T lymphocytes: Similarity to antigen-presenting cells. Pathology International, 63: 85–93. doi: 10.1111/pin.12036
- Issue published online: 7 MAR 2013
- Article first published online: 22 FEB 2013
- Manuscript Accepted: 17 JAN 2013
- Manuscript Received: 16 SEP 2012
- National Hospital Organization Collaborative Clinical Research Grants
- the Ministry of Education, Culture, Sports, Science and Technology
Figure S1 Immunohistochemical characterization of a granuloma in a case of tuberculous pleuritis in an exudative area. HE (A) and immunohistochemistry (brown color) for CD205 (B), CD83 (C) and CD3 (D). Differentiation of epitheloid cells is incomplete in this granuloma (early phase). The expression of CD83 is extensive here, particularly in giant cells. Note expression of CD205 and presence of intra-granuloma T cells. Blue dots indicate the area of granuloma cells. Scale bars: 50 μm.
Figure S2 Immunohistochemical characterization of a granuloma in a case of tuberculous bursitis. HE (A) and immunohistochemistry (brown stain) for CD205 (B), CD4 (C) and CD8 (D). Note that CD4+ cells predominate over CD8+ cells among intra-granuloma T cells. CD205 is clearly expressed in most granuloma cells. Scale bars: 50 μm.
Figure S3 Immunoshitochemistry for CD205 in a case of foreign body reaction (epidermal cyst) associated with chronic inflammation. HE (A) and CD205 immunostain (B). This granuloma is situated in the vicinity of epidermal cyst. Note that mononuclear foreign body granuloma cells occasionally express CD205 where lymphocytes are distributed. Scale bars: 100 μm.
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