Conflict of interest and funding disclosures: None declared.
Multifocal and microscopic chromophobe renal cell carcinomatous lesions associated with ‘capsulomas’ without FCLN gene abnormality
Article first published online: 18 OCT 2013
© 2013 The Authors. Pathology International © 2013 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd
Volume 63, Issue 10, pages 510–515, October 2013
How to Cite
Sugimoto, K., Takasawa, A., Ichimiya, S., Murata, M., Kimura, H., Aoyama, T., Gille, J. J.P., Kuroda, N., Shimizu, H., Hasegawa, T., Sawada, N., Furuya, M. and Nagashima, Y. (2013), Multifocal and microscopic chromophobe renal cell carcinomatous lesions associated with ‘capsulomas’ without FCLN gene abnormality. Pathology International, 63: 510–515. doi: 10.1111/pin.12099
- Issue published online: 22 OCT 2013
- Article first published online: 18 OCT 2013
- Manuscript Accepted: 30 AUG 2013
- Manuscript Received: 15 JUL 2013
- chromophobe renal cell carcinoma;
Chromophobe renal cell carcinoma (RCC) accounts for approximately 5% of renal epithelial neoplasms. Multiple and/or bilateral chromophobe RCCs in an individual are generally rare but frequently occur in patients with Birt–Hogg–Dubé syndrome (BHDS) and in patients with tuberous sclerosis complex (TSC). The responsible genes in both BHDS and TSC act as tumor suppressors. Therefore, it seems that some genetic backgrounds are required for the generation and progression of multiple chromophobe RCCs. Here, we report a case of multiple and bilateral chromophobe RCCs along with several small-sized capsular angiomyolipomas known as ‘capsulomas’ in a 39-year-old woman who had neither a particular medical history nor specific gene mutation. There has been no report of sporadic multiple chromophobe RCCs and ‘capsulomas’ developing in a patient without genetic features, having potential for novel genetic variation.