Disclosure statement: The authors have no conflicts of interest to declare.
Nestin is a wide-spectrum abluminal cell marker of salivary gland tumors
Article first published online: 18 OCT 2013
© 2013 The Authors. Pathology International © 2013 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd
Volume 63, Issue 10, pages 496–501, October 2013
How to Cite
Yanai, H., Sato, Y., Nagatsuka, H. and Yoshino, T. (2013), Nestin is a wide-spectrum abluminal cell marker of salivary gland tumors. Pathology International, 63: 496–501. doi: 10.1111/pin.12103
- Issue published online: 22 OCT 2013
- Article first published online: 18 OCT 2013
- Manuscript Accepted: 19 SEP 2013
- Manuscript Received: 9 APR 2013
- abluminal cells;
- basal cells;
- myoepithelial cells;
- salivary gland tumors
Nestin is an intermediate filament that was first identified in neural progenitor cells. It is expressed in various cell types in the nervous system as well as in other systems. In the present study, we investigated nestin expression in non-neoplastic salivary gland tissue and in salivary gland tumors. In non-neoplastic salivary glands, nestin expression was observed in only a few abluminal cells. In contrast, diffuse nestin staining was observed in the abluminal cells of pleomorphic adenoma (11 of 11 cases), basal cell adenoma (7 of 7 cases), and epithelial-myoepithelial carcinoma (2 of 2 cases). The stromal cells in basal cell adenoma also expressed nestin. In adenoid cystic carcinoma (6 of 7 cases) and polymorphous low-grade adenocarcinoma (3 of 3 cases), nestin positive cells were observed focally. Nestin was not detected in Warthin tumor (6 cases), classical acinic cell carcinoma (2 cases), mucoepidermoid carcinoma (5 cases), or salivary duct carcinoma (4 cases). Because the nestin expression pattern in each histological salivary gland tumor type is unique, nestin could be a very useful abluminal cell marker for the diagnosis of salivary gland tumors.