Conflict of interest: None declared.
Distribution of myofibroblast and tenascin-C in cystic adventitial disease: Comparison with ganglion
Article first published online: 15 JAN 2014
© 2013 The Authors. Pathology International © 2013 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd
Volume 63, Issue 12, pages 591–598, December 2013
How to Cite
Hao, H., Ishibashi-Ueda, H., Nishida, N., Kawakami, R., Tsukamoto, Y., Tsujimoto, M. and Hirota, S. (2013), Distribution of myofibroblast and tenascin-C in cystic adventitial disease: Comparison with ganglion. Pathology International, 63: 591–598. doi: 10.1111/pin.12119
- Issue published online: 15 JAN 2014
- Article first published online: 15 JAN 2014
- Manuscript Accepted: 14 NOV 2013
- Manuscript Received: 1 AUG 2013
- Grant-in-Aid for Scientific Research (C) (JSPS KAKENHI). Grant Number: 24590435
- alpha-smooth muscle actin;
- cystic adventitial disease;
- popliteal artery;
Cystic adventitial disease (CAD) is a rare peripheral artery disorder which shows the development of gelatinous cysts in the adventitia. Although several theories for the pathogenesis of CAD have been postulated, the etiology of CAD remains unclear. Histological examination of three CAD cases revealed that these cyst walls were composed of fibrous tissue and lacked both epithelial and endothelial lining. The surfaces of these cysts were partially covered with spindle-shaped cells, similar to the interstitial cells within the cyst wall. A pool of mucinous material in the adventitia was evident. Distribution of vimentin-positive spindle-shaped cells and scattered CD68-positive oval-shaped cells in the cyst wall was revealed by immunohistochemistry. A part of vimentin-positive spindle-shaped cells demonstrated to be positive for α-smooth muscle actin, indicating the presence of myofibroblasts in the cyst wall. A focal tenascin-C-positive area was observed in the cyst wall of our CAD cases. Presence of two different cell types, proliferation of myofibroblasts and expression of tenascin-C were consistent with those of cyst walls of 20 surgically resected ganglions. These results suggest that CAD may arise as capsular synovial structures, similar to ganglion cysts.