These authors share the first authorship as they contributed equally to this work.
A case of diffuse infiltrating gastrointestinal stromal tumor of sigmoid colon with perforation
Article first published online: 29 JAN 2014
© 2014 The Authors. Pathology International © 2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd
Volume 64, Issue 1, pages 34–38, January 2014
How to Cite
Yamashita, D., Usami, Y., Toyosawa, S., Hirota, S. and Imai, Y. (2014), A case of diffuse infiltrating gastrointestinal stromal tumor of sigmoid colon with perforation. Pathology International, 64: 34–38. doi: 10.1111/pin.12124
Disclosure: The authors declare that they have no conflicts of interest.
- Issue published online: 29 JAN 2014
- Article first published online: 29 JAN 2014
- Manuscript Accepted: 29 NOV 2013
- Manuscript Received: 14 AUG 2013
- acute abdomen;
- acute peritonitis;
- gastrointestinal neoplasia;
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and typically present as discrete well-circumscribed but non-encapsulated tumor masses. In this report, we describe a case of colonic perforation caused by an unusual form of GIST. A 72-year-old Japanese woman presented to the emergency department with acute abdominal pain. Under the provisional diagnosis of sigmoid colon perforation, a laparoscopic sigmoidectomy was performed. Although the tumor mass was undetectable during the preoperative examination, a spindle cell lesion with a diffuse longitudinal growth pattern replacing the muscularis propria was revealed by microscopic examination. The spindle cell lesion was exposed at the perforation, suggesting a causal relationship between the lesion and the perforation. The spindle cell lesion was KIT-positive and had a mutation in the C-KIT gene at exon 11. We diagnosed it as diffuse infiltrating GIST. We consider that the lesion would be a cause of the colonic perforation, and emphasize the importance of accurate diagnosis of the lesion by histological, immunohistochemical and genetic examinations.