Conflict of Interest/Disclosure Summary: Dr. Pickthorn, Dr. Huang, and Dr. Bell are employees and stockholders of KAI Pharmaceuticals, Inc.
Original Research Article
A Single-Center, Randomized, Double-Blind, Active, and Placebo-Controlled Study of KAI-1678, a Novel PKC-Epsilon Inhibitor, in the Treatment of Acute Postoperative Orthopedic Pain
Article first published online: 8 APR 2013
Wiley Periodicals, Inc
Volume 14, Issue 6, pages 916–924, June 2013
How to Cite
Moodie, J. E., Bisley, E. J., Huang, S., Pickthorn, K. and Bell, G. (2013), A Single-Center, Randomized, Double-Blind, Active, and Placebo-Controlled Study of KAI-1678, a Novel PKC-Epsilon Inhibitor, in the Treatment of Acute Postoperative Orthopedic Pain. Pain Medicine, 14: 916–924. doi: 10.1111/pme.12088
Brief summary of article: Nociceptive properties of protein kinase C (PKC) has been studied for nearly two decades. We found that KAI-1678—a novel inhibitor of epsilon PKC—was not an analgesic for patients with postoperative pain following total hip or total knee replacement surgery. However, a different PKC inhibitor may prove to be a safe and effective analgesic.
- Issue published online: 20 JUN 2013
- Article first published online: 8 APR 2013
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