Disclosure information/Acknowledgment of support: No other staff has been involved in this study.
Original Research Article
Experimental Knee Pain Evoke Spreading Hyperalgesia and Facilitated Temporal Summation of Pain
Article first published online: 16 APR 2013
Wiley Periodicals, Inc
Volume 14, Issue 6, pages 874–883, June 2013
How to Cite
Joergensen, T. S., Henriksen, M., Danneskiold-Samsoee, B., Bliddal, H. and Graven-Nielsen, T. (2013), Experimental Knee Pain Evoke Spreading Hyperalgesia and Facilitated Temporal Summation of Pain. Pain Medicine, 14: 874–883. doi: 10.1111/pme.12093
TSJ: main author of the manuscript; data collection, data analysis and writing.
MH: contributed to the analysis and discussed and commented on the whole paper.
BDS: discussed and commented on the whole paper and protocols.
HB: discussion and commented on the whole paper and protocols.
TGN: main responsible for outlining the manuscript, discussing, and commenting on the paper during the whole process.
Experimental knee pain leads to hyperalgesia at the knee and facilitated temporal summation of pain outside the knee, indicating involvement of peripheral and central sensitization, in subjects with no history of knee pain. Experimental models of knee pain in healthy subjects may be advantageous to investigate mechanisms of the nociceptive system related to joint pain without any unwanted variability.
- Issue published online: 20 JUN 2013
- Article first published online: 16 APR 2013
- Oak Foundation
- Center for Sensory Motor Interaction (SMI) at Aalborg University
- The Danish Agency for Science Technology and Innovation (FI)
- Knee Pain;
- Knee OA;
- Temporal Summation;
- Pressure Algometry
This study evaluated the deep-tissue pressure pain sensitivity and temporal summation of pain within and around healthy knees exposed to experimental pain.
The study was designed as a randomized crossover trial, with each subject tested on 1 day.
All tests were carried out at the Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology at Aalborg University, Denmark.
Seventeen healthy subjects (10 males) participated in this study.
Experimental pain model. Pain was induced in the infrapatellar fat pad by injection of hypertonic saline and the contralateral infrapatellar fat pad was injected with isotonic saline as control.
Pressure pain thresholds, temporal summation of pressure pain, and cutaneous mechanosensitivity were assessed on three occasions: baseline, immediately after the injection, and when pain had vanished. Assessments sites were located in the peripatellar region, vastus lateralis, and tibialis anterior muscles.
The experimental knee pain model demonstrated 1) hyperalgesia to pressure stimulation on the infrapatellar fat pad during experimental pain, and 2) facilitated temporal summation of pressure pain at the infrapatellar fat pad and knee-related muscles.
The increased sensitivity and temporal summation found in this study were exclusive to deep -tissue with no contralateral decreased pain sensitivity. The study showed that acute knee joint pain leads to hyperalgesia and facilitated temporal summation in the infrapatellar fat pad and in muscles located distant to the injection site, in subjects with no history of knee pain.