Duration of Migraine Is Associated with Cardiac Diastolic Dysfunction

Authors


  • Disclosure: The authors report no conflicts of interest.
  • Authors' Contributions: BE has contributed in conception and design, acquisition of data, analysis and interpretation of data, and involved in drafting and revising the manuscript; IUC has contributed in conception and design, coordination, acquisition analysis, and interpretation of data, and involved in drafting and revising the manuscript critically for important intellectual content; EAE has contributed in acquisition of data, analysis and interpretation of data, and involved in revising the manuscript; GM has contributed in acquisition of data, analysis, and interpretation of data; YY has contributed in statistical analysis and interpretation of data, AFE has contributed in design of the manuscript. All authors read and approved the final manuscript.
  • Authors' Information: BE is staff cardiologist in Ufuk University Faculty of Medicine, Department of Cardiology; IUC is a neurologist, neuroscientist, and pain specialist, currently Professor and the chairperson in Ufuk University Faculty of Medicine Department of Neurology; EAE is Associate Professor and cardiologist in Ufuk University Faculty of Medicine, Department of Cardiology; GM is the chief neurology resident in Ufuk University Faculty of Medicine Department of Neurology; YY is currently Professor in Hacettepe University Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation; AFE is Assistant Professor and cardiologist in Ufuk University Faculty of Medicine, Department of Cardiology.

Reprint requests to: Isin Unal-Cevik, MD, PhD, Department of Neurology, Faculty of Medicine, Ufuk University, Balgat, 06520-Ankara, Turkey. Tel: +90(312) 204-4000; Fax: +90(312) 287-2390; E-mail: isin.unalcevik@gmail.com.

Abstract

Objective.

Migraine is a common type of headache accompanied or preceded by signs of central and autonomic nervous system dysfunction. Autonomic dysfunction has been suggested to be a potential contributor to impaired cardiac diastolic function. Cardiac diastolic dysfunction is characterized by normal left ventricular contractility but impaired ventricular relaxation. It is a growing clinical entity implicated in morbidity and mortality due to heart failure. The aim of this study was to determine if any relationship exists between migraine and diastolic dysfunction.

Methods.

Migraineurs (N = 55), and age- and sex-matched healthy controls (N = 52) were evaluated by conventional and tissue Doppler echocardiography. Migraine-related disability in the previous 3 months was assessed by the Migraine Disability Assessment questionnaire. Baseline characteristics were recorded, and blood samples were collected.

Results.

The groups did not differ in terms of sex or age. The migraine group had higher lipid levels compared with the control group. Diastolic dysfunction was significantly higher among the 30 migraineurs with a history of migraine of 10 years or more compared with the 25 migraineurs with a history of less than 10 years, (P = 0.003). In logistic regression analysis, migraine duration was shown to be an independent predictor of diastolic dysfunction (odds ratio 1.130, 95% confidence interval, P = 0.044).

Conclusions.

Cardiac diastolic dysfunction is associated with migraine. A long history of migraine is an independent predictor of diastolic dysfunction.

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