Get access

Analgesic Effects of Microwave Ablation of Bone and Soft Tissue Tumors Under Local Anesthesia

Authors

  • Adrian Kastler MD, MSc,

    Corresponding author
    1. Neuroradiology Department, CLUNI, University Hospital, Grenoble, France
    2. I4S Laboratory—EA 4268-IFR 133, Franche Comté University, Besançon, France
    • Reprint requests to: Adrian Kastler, MD, I4S Laboratory, IFR 133 EA 4268, Franche Comté University, 1 place St Jacques, 25000 Besançon, France. Tel: (+33) 6-75-4967-38; Fax: (+33) 381-668-495; E-mail: adriankastler@gmail.com.

    Search for more papers by this author
  • Hussein Alnassan MSc,

    1. I4S Laboratory—EA 4268-IFR 133, Franche Comté University, Besançon, France
    Search for more papers by this author
  • Philippe L. Pereira MD, PhD,

    1. Department of Radiology, Minimally Invasive Therapies and Nuclearmedicine SLK-Kliniken-Academic Hospital, Ruprecht-Karls-University, Heidelberg, Germany
    Search for more papers by this author
  • Guillaume Alemann MD,

    1. I4S Laboratory—EA 4268-IFR 133, Franche Comté University, Besançon, France
    2. Radiology and Interventional Pain Unit, CHU Jean Minjoz, Besançon, France
    Search for more papers by this author
  • Daniel-Ange Barbé MD,

    1. I4S Laboratory—EA 4268-IFR 133, Franche Comté University, Besançon, France
    2. Radiology and Interventional Pain Unit, CHU Jean Minjoz, Besançon, France
    Search for more papers by this author
  • Sébastien Aubry MD, PhD,

    1. I4S Laboratory—EA 4268-IFR 133, Franche Comté University, Besançon, France
    2. Radiology and Interventional Pain Unit, CHU Jean Minjoz, Besançon, France
    Search for more papers by this author
  • Florence Tiberghien MD,

    1. Pain Evaluation and Treatment Unit, University Hospital Jean Minjoz, Besançon, France
    Search for more papers by this author
  • Bruno Kastler MD, PhD

    1. I4S Laboratory—EA 4268-IFR 133, Franche Comté University, Besançon, France
    2. Radiology and Interventional Pain Unit, CHU Jean Minjoz, Besançon, France
    Search for more papers by this author

  • Disclosure: Authors have nothing to disclose.
  • No financial support or conflicts of interest are declared.

Abstract

Objective

To assess the feasibility and efficacy of microwave ablation (MWA) of painful refractory bone and soft tissue tumors performed under local anesthesia.

Study Design

A retrospective study between 2011 and 2013.

Setting

A single center, Academic Interventional Pain Management Unit.

Subjects

Fifteen patients with 25 refractory painful bone (N = 19) or soft tissue (N = 6) tumors treated with MWA were consecutively included.

Method

Local Institutional Review Board approval was obtained, and written informed consent was waived. Lesions included spinal (N = 3), sacral (N = 4), and extraspinal (N = 18) locations. Pain was measured on a visual analog scale (VAS) from 0 to 10 before and immediately after procedure, at 1 week, and on a monthly basis following procedure. MWA procedures were always performed under computed tomography guidance and local anesthesia along with nitrous oxide inhalation.

Results

Mean ablation time was 4.09 minutes (range 1–11) with an average of 4.2 cycles with a mean ablation power of 60 W. Preprocedure mean VAS score was 7.2 ± 0.97 (range 6–9). Follow-up postprocedure VAS scores were as follows: day 0: 1.64 ± 1.86, day 7: 1.82 ± 1.79, month 1: 2.05 ± 2.03 (14/15 patients), month 3: 2.13 ± 1.81, month 6: 2.36 ± 2.17; and were statistically significant (P < 0.001). Mean pain relief was 5.5 months.

Conclusion

MWA is feasible, safe, and effective in the management of painful refractory bone and soft tissue tumors. It may therefore be considered as a potential alternative to existing percutaneous ablation techniques in the management of bone and soft tissue tumors.

Get access to the full text of this article

Ancillary