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Peripheral Nerve Adjustment for Postherpetic Neuralgia: A Randomized, Controlled Clinical Study

Authors

  • Ke Ma PhD,

    1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai, China
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    • Authors contributed equally to this work.
  • Quan-hong Zhou PhD,

    1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai, China
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    • Authors contributed equally to this work.
  • Yong-ming Xu MD,

    1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai, China
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    • Authors contributed equally to this work.
  • Tao Xu PhD,

    1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai, China
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    • Authors contributed equally to this work.
  • Dong-ping Du PhD,

    1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai, China
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  • Xiaohui Huang PhD,

    1. College of Pharmacy, Anhui Medical University, Heifei, China
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  • Wei Jiang PhD

    Corresponding author
    1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai, China
    • Reprint requests to: Wei Jiang, PhD, Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai JiaoTong University, 600 Yi-Shan Road, Shanghai 200233, China. Tel: +86-21-64369181; Fax: +86-21-64368920; E-mail: jiangw@sjtu.edu.cn.

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  • Conflicts of interest: There are no conflicts of interest.
  • Clinical Trials registration number: ISRCTN58767633.

Abstract

Objective

To observe the therapeutic effect of peripheral nerve adjustment for the treatment of postherpetic neuralgia (PHN).

Methods

One hundred and two patients with PHN were randomly assigned to three groups; the control group (A), the experimental group (B), which was subjected to peripheral nerve adjustment, and patients who received a sham peripheral nerve adjustment, thus serving as a positive control group (C). The patients' Visual Analogue Scale (VAS) and total oral rescue dosage for pain management were recorded at days 1, 3, 7, 14, and 28 following treatment. Quality of life (QOL), 36-Item Short-Form Health Survey (SF-36), and side effects were recorded following treatment.

Results

We observed that the average VAS score was significantly lower in the treatment group (B) than in the control groups A and C following treatment (P < 0.05). In addition, the QOL and SF-36 scores for group B improved substantially following treatment compared to groups A and C, and this effect was maintained up to 180 days after treatment (P < 0.05). The average dosage of pain medication was also lower in group B, compared to groups A and C, following treatment (P < 0.05).

Conclusions

We conclude that peripheral nerve adjustment can relieve PHN pain and improve patients' quality of life. The possible mechanisms involved may include the reduction of both peripheral and central sensitization, the modulation of nerve plasticity, and an increase in endogenous analgesic molecules.

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