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pme12267-sup-0001-si.jpg72KFigure S1 PAG resting functional connectivity in migraineurs vs controls. The strength of 14 functional connections with PAG differed in migraine subjects (red circles on scatterplot) compared with controls (blue diamonds on scatterplot). Average functional connectivity strength is demonstrated with open red circles (migraineurs) and open blue diamonds (controls). The locations of voxels in each region included in the scatterplot and the location of the PAG seed are shown on the brain slices. Red coloration of voxels indicates that PAG functional connectivity is more positive in migraineurs compared with controls. Blue coloration of voxels indicates that PAG functional connectivity is more negative in migraineurs compared with controls. Axial slices are shown with the left hemisphere on the left side.
pme12267-sup-0002-si.pdf140KFigure S2 NCF resting functional connectivity in migraineurs vs controls. The strength of 12 functional connections with NCF differed in migraine subjects (red circles on scatterplot) compared with controls (blue diamonds on scatterplot). Average functional connectivity strength is demonstrated with open red circles (migraineurs) and open blue diamonds (controls). The locations of voxels in each region included in the scatterplot and the location of the NCF seed are shown on the brain slices. Red coloration of voxels indicates that NCF functional connectivity is more positive in migraineurs compared with controls. Blue coloration of voxels indicates that NCF functional connectivity is more negative in migraineurs compared with controls. Axial slices are shown with the left hemisphere on the left side.
pme12267-sup-0003-si.jpg7KFigure S3 Overlap between PAG rs-fc that differs in severely allodynic vs non-allodynic migraineurs and in migraineurs vs controls. Voxels colored in yellow are those voxels that have rs-fc strength to PAG that differs in migraineurs with severe allodynia vs migraineurs with no allodynia and in migraineurs vs controls. Green- and purple-colored voxels are those that have rs-fc strength to PAG that differs in migraineurs with severe allodynia vs migraineurs with no allodynia or in migraineurs vs controls, but not in both contrasts.

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