Conflict of Interest
Long-Term Benzodiazepine Use in Patients With Major Depressive Disorder in China
Article first published online: 1 AUG 2013
© 2013 Wiley Periodicals, Inc
Perspectives in Psychiatric Care
Volume 50, Issue 3, pages 149–154, July 2014
How to Cite
Li, Y.-H., Xiang, Y.-T., Su, Y.-A., Shu, L., Yu, X., Kilbourne, A. M., Ungvari, G. S., Chiu, H. F.K., Ma, C., Wang, G.-H., Bai, P.-S., Liu, X.-H., Sun, L.-Z., Shi, J.-G., Chen, X.-S., Mei, Q.-Y., Li, K.-Q. and Si, T.-M. (2014), Long-Term Benzodiazepine Use in Patients With Major Depressive Disorder in China. Perspectives in Psychiatric Care, 50: 149–154. doi: 10.1111/ppc.12035
The authors have no conflict of interest.
- Issue published online: 7 JUL 2014
- Article first published online: 1 AUG 2013
- Manuscript Accepted: 27 JUN 2013
- Manuscript Revised: 20 JUN 2013
- Manuscript Received: 1 MAY 2013
- major depressive disorder;
- prescribing patterns
There have been no data about long-term benzodiazepine (BZD) use and its correlates in patients with major depressive disorder (MDD) in China. This study aimed to examine the prevalence of long-term BZD use (more than three months) and its demographic and clinical correlates in Chinese patients with MDD.
Design and Methods
A total of 1,192 patients with MDD were examined in 10 mental health centers in China. Patients' socio-demographic and clinical characteristics and prescriptions for psychotropic drugs were recorded using a standardized form.
A large portion of patients (36.2%) received long-term BZD treatment. Univariate analyses revealed that long-term BZD users were older, poorer, and had more impaired occupational functioning than patients not taking BZDs. Long-term BZD users had fewer psychotic symptoms and took less antipsychotic drugs. In multivariate analyses, long-term BZD use was independently associated with older age and more severe impaired occupational functioning; long-term BZD users were less likely to receive antipsychotic medications and traditional antidepressants (tricyclic antidepressants, tetracyclic antidepressant, and monoamine oxidase inhibitors).
Long-term BZD use was common in patients with MDD in China. A host of demographic and clinical factors were independently associated with long-term BZD use.