These authors equally contributed to this work.
Frequency of Hyperprolactinemia and Its Associations With Demographic and Clinical Characteristics and Antipsychotic Medications in Psychiatric Inpatients in China
Article first published online: 20 NOV 2013
© 2013 Wiley Periodicals, Inc
Perspectives in Psychiatric Care
Volume 50, Issue 4, pages 257–263, October 2014
How to Cite
Wang, Z.-M., Xiang, Y.-T., An, F.-R., Correll, C. U., Ungvari, G. S., Wang, C.-Y., Lai, K. Y. C., Bo, Q.-J., Li, Y., Zhong, B.-L. and Chiu, H. F. K. (2014), Frequency of Hyperprolactinemia and Its Associations With Demographic and Clinical Characteristics and Antipsychotic Medications in Psychiatric Inpatients in China. Perspectives in Psychiatric Care, 50: 257–263. doi: 10.1111/ppc.12050
- Issue published online: 16 OCT 2014
- Article first published online: 20 NOV 2013
- Manuscript Accepted: 15 OCT 2013
- Manuscript Revised: 28 SEP 2013
- Manuscript Received: 16 JUL 2013
- National Natural Science Foundation of China. Grant Numbers: 81171270, 30800367, 30770776
- Beijing Nova Program of the Beijing Municipal Science and Technology Commission. Grant Number: 2008B59
- Antipsychotic medication;
No study has investigated hyperprolactinemia and its risk factors in Chinese psychiatric patients. This study examined the prevalence of hyperprolactinemia and its relationship with demographic and clinical characteristics in inpatients in a large psychiatric institution in Beijing, China.
Design and Methods
A consecutive sample of 617 psychiatric inpatients formed the study sample. Basic sociodemographic and clinical data including serum prolactin level were collected.
The prevalence of hyperprolactinemia was 55.9% in the whole sample, and 56.8% and 43.2% for women and men, respectively. The corresponding figures were 59.6%, 40.0%, 53.6%, and 50.8% in schizophrenia spectrum disorders, major depression, bipolar disorders, and other psychiatric disorders, respectively (p = 0.09). In univariate analyses, patients having hyperprolactinemia were younger, more likely to receive risperidone, amisulpride, and first-generation antipsychotics, but less likely to receive clozapine and aripiprazole. In multiple logistic regression analysis, hyperprolactinemia was independently associated with younger age, more use of risperidone or amisulpride and first-generation antipsychotics, and less use of clozapine and aripiprazole (r2 = 0.197).
Hyperprolactinemia is very common in Chinese psychiatric inpatients. Given the potentially harmful consequences of hyperprolactinemia and its preventable nature, effective measures to lower the frequency hyperprolactinemia in patients with major psychiatric disorders should be implemented in Chinese mental health facilities.