Fetal Growth & Preterm Delivery
Maternal Birthweight Is Associated with Subsequent Risk of Vitamin D Deficiency in Early Pregnancy
Article first published online: 12 JUL 2013
© 2013 John Wiley & Sons Ltd
Paediatric and Perinatal Epidemiology
Volume 27, Issue 5, pages 472–480, September 2013
How to Cite
Huang, J. Y., Qiu, C., Miller, R. S., Siscovick, D. S., Williams, M. A. and Enquobahrie, D. A. (2013), Maternal Birthweight Is Associated with Subsequent Risk of Vitamin D Deficiency in Early Pregnancy. Paediatric and Perinatal Epidemiology, 27: 472–480. doi: 10.1111/ppe.12069
- Issue published online: 11 AUG 2013
- Article first published online: 12 JUL 2013
- National Institutes of Health. Grant Numbers: HD/HL 355566, 2T32HD052462-06, 1K01HL103174
- vitamin D;
Maternal low birthweight and vitamin D deficiency in pregnancy are associated with a similar spectrum of adverse pregnancy outcomes including pre-eclampsia and gestational diabetes. However, the relationship between maternal birthweight and subsequent vitamin D concentrations in early pregnancy is largely unknown.
We assessed whether self-reported maternal birthweight was associated with risk of early pregnancy vitamin D deficiency (≤20 ng/mL) among a pregnancy cohort (n = 658). Serum 25-hydroxyvitamin D [25(OH)D] was measured using liquid chromatography-tandem mass spectroscopy.
Adjusting for maternal characteristics and month of blood draw, a 100-g higher maternal birthweight was associated with a 5.7% decreased risk of early pregnancy 25(OH)D deficiency [odds ratio (OR) = 0.94; 95% confidence interval (CI) 0.90, 0.99]. Low-birthweight (<2500 g) women were 3.7 times as likely to have early pregnancy 25(OH)D deficiency compared with normal-birthweight women [OR = 3.69; 95% CI 1.63, 8.34]. These relationships were not modified by either pre-pregnancy overweight status [body mass index (BMI) ≥25 kg/m2] or adulthood weight trajectory (BMI change ≥2 kg/m2 from age 18 to pre-pregnancy).
Further research on shared developmental mechanisms that determine birthweight and vitamin D homeostasis may help identify targets and related preventative measures for adverse pregnancy and birth outcomes.